Molecular structure of Diazoxide, CAS Number: 364-98-7
Diazoxide (CAS 364-98-7)
See product citations (5)
Alternate Names:
7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Application:
Diazoxide is a selective ATP-dependent K+ (Kir6) channel activator
CAS Number:
364-98-7
Purity:
≥98%
Molecular Weight:
230.67
Molecular Formula:
C8H7ClN2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Diazoxide, a white crystalline powder, serves as a valuable compound in research on blood vessels. Diazoxide′s solubility in water, ethanol, and methanol further contribute to its versatility. Additionally, Diazoxide is a benzothiadiazine derivative which functions as a selective KIR6 (ATP-dependent K+) channel activator and calcium channel blocker. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in smooth muscle. Studies suggest that Diazoxide acts as a peripheral vasodilator. In addition, Diazoxide is used in diabetic studies to increase glucose concentrations in plasma, inhibit the secretion of insulin by beta cells of the pancreas, increase the release of catecholamines, and hepatic output of glucose in vitro.
Diazoxide (CAS 364-98-7) References
- The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim. | Newgreen, DT., et al. 1990. Br J Pharmacol. 100: 605-13. PMID: 2167738
- Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells. | Dunne, MJ., et al. 1990. J Membr Biol. 114: 53-60. PMID: 2181144
- Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. | Trube, G., et al. 1986. Pflugers Arch. 407: 493-9. PMID: 2431383
- In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide. | Quast, U. and Cook, NS. 1989. J Pharmacol Exp Ther. 250: 261-71. PMID: 2501478
- Diazoxide accelerates wound healing by improving EPC function. | Li, ZP., et al. 2016. Front Biosci (Landmark Ed). 21: 1039-51. PMID: 27100489
- Diazoxide prevents reactive oxygen species and mitochondrial damage, leading to anti-hypertrophic effects. | Lucas, AM., et al. 2017. Chem Biol Interact. 261: 50-55. PMID: 27867086
- Effect of diazoxide on Friedreich ataxia models. | Santoro, A., et al. 2018. Hum Mol Genet. 27: 992-1001. PMID: 29325032
- Randomised controlled trial of diazoxide for small for gestational age neonates with hyperinsulinaemic hypoglycaemia provided early hypoglycaemic control without adverse effects. | Balachandran, B., et al. 2018. Acta Paediatr. 107: 990-995. PMID: 29385640
- Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity. | Pecoraro, M., et al. 2018. Int J Mol Sci. 19: PMID: 29518932
- Remote Ischemic Preconditioning and Diazoxide Protect from Hepatic Ischemic Reperfusion Injury by Inhibiting HMGB1-Induced TLR4/MyD88/NF-κB Signaling. | Koh, WU., et al. 2019. Int J Mol Sci. 20: PMID: 31771292
- Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale. | Akopova, O., et al. 2020. BMC Mol Cell Biol. 21: 31. PMID: 32306897
- Diazoxide and Exercise Enhance Muscle Contraction during Obesity by Decreasing ROS Levels, Lipid Peroxidation, and Improving Glutathione Redox Status. | Gómez-Barroso, M., et al. 2020. Antioxidants (Basel). 9: PMID: 33291828
- Necrotizing Enterocolitis in Neonates With Hyperinsulinemic Hypoglycemia Treated With Diazoxide. | Keyes, ML., et al. 2021. Pediatrics. 147: PMID: 33483452
- Exploring diazoxide and continuous glucose monitoring as treatment for Glut1 deficiency syndrome. | Logel, SN., et al. 2021. Ann Clin Transl Neurol. 8: 2205-2209. PMID: 34612610
- Diazoxide during pregnancy and lactation: drug levels in maternal serum, cord blood, breast milk, and infant serum: a case report. | Saito, J., et al. 2022. Gynecol Endocrinol. 38: 528-530. PMID: 35403531
Inhibitor of:
ATP13A3, ATP8B5, Caytaxin, KCNRG, KRTAP9-2, Olr437, PTP IA-2β, Reg II, SLC30, STOML2, SUR-1, SUR1, SVCT2, THTR1, TRMP6, ZnT-6, and ZnT-8.Activator of:
5830482F20Rik, A130010J15Rik, AChRβ3, ACYP1, AI747448, ATP13A3, C5orf28, CaBP8, CLC-4, CLIC2, E330016A19Rik, FAM26A, GCG, GlyR α2, GPR139, Insulin, KCNE1L, KCNMB4, Kctd12b, KCTD4, KIR, KIR3.1, KIR6.1, KIR6.2, KV4.1, Mimp, Olfr433, ORMDL1, OTTMUSG00000019786, Ovol2, parvalbumin β, Potassium Chloride, PYGB, RIM-BP2, Sacsin, SLC12A8, SLITRK4, TRESK, urocortin, and Xin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diazoxide, 1 g | sc-200980 | 1 g | $300.00 |