Date published: 2025-10-21
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Exendin-3 (9-39) (CAS 133514-43-9) - chemical structure image
Molecular structure of Exendin-3 (9-39), CAS Number: 133514-43-9
Exendin-3 (9-39) (CAS 133514-43-9) - chemical structure image
Molecular structure of Exendin-3 (9-39), CAS Number: 133514-43-9
Molecular structure of Exendin-3 (9-39), CAS Number: 133514-43-9

Exendin-3 (9-39) (CAS 133514-43-9)

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Application:
Exendin-3 (9-39) is a potent and selecive GLP-1 receptor antagonist.
CAS Number:
133514-43-9
Molecular Weight:
3369.79
Molecular Formula:
C149H234N40O47S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

Exendin-3 (9-39) is a peptide fragment that has interest in biological research, particularly in the study of endocrine functions. As an antagonist of the glucagon-like peptide-1 receptor (GLP-1R), it is widely used to elucidate the role of this receptor in glucose homeostasis and appetite control. Researchers utilize Exendin-3 (9-39) to explore the complex signaling pathways of GLP-1 and its effects on insulin secretion, making it useful in diabetes research. Furthermore, this peptide is instrumental in investigations related to gastric motility and the enteroendocrine system, providing insights into the broader implications of GLP-1R signaling beyond glycemic control. Exendin-3 (9-39) also serves as a critical component in the development of assays for the characterization of GLP-1R agonists and antagonists. The specificity of Exendin-3 (9-39) for GLP-1R makes it particularly useful for dissecting the physiological functions of this receptor in various tissues.


Exendin-3 (9-39) (CAS 133514-43-9) References

  1. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice.  |  Ahrén, B. and Pacini, G. 1999. Am J Physiol. 277: E996-E1004. PMID: 10600787
  2. PACAP contributes to insulin secretion after gastric glucose gavage in mice.  |  Filipsson, K., et al. 2000. Am J Physiol Regul Integr Comp Physiol. 279: R424-32. PMID: 10938228
  3. The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice.  |  Cluny, NL., et al. 2009. Neurogastroenterol Motil. 21: 420-9. PMID: 19140957
  4. Receptor identification and physiological characterisation of glucagon-like peptide-2 in the rat heart.  |  Angelone, T., et al. 2012. Nutr Metab Cardiovasc Dis. 22: 486-94. PMID: 21186112
  5. Roux-en-Y gastric bypass in rats increases sucrose taste-related motivated behavior independent of pharmacological GLP-1-receptor modulation.  |  Mathes, CM., et al. 2012. Am J Physiol Regul Integr Comp Physiol. 302: R751-67. PMID: 22170618
  6. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.  |  Wang, YG. and Yang, TL. 2015. J Geriatr Cardiol. 12: 410-6. PMID: 26346224
  7. Glucagon-Like Peptide-1 Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells Under Basal and Hyperglycemia Conditions.  |  Fukuda, S., et al. 2016. J Mol Neurosci. 59: 211-9. PMID: 26659380
  8. Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9-39) in a normoglycemic mouse model.  |  Haufe, TC., et al. 2016. Food Funct. 7: 2692-705. PMID: 27189193
  9. Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways.  |  Farkas, I., et al. 2016. Front Cell Neurosci. 10: 214. PMID: 27672360
  10. Development of 111In-labeled exendin(9-39) derivatives for single-photon emission computed tomography imaging of insulinoma.  |  Kimura, H., et al. 2017. Bioorg Med Chem. 25: 1406-1412. PMID: 28089587
  11. APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice.  |  Bahirat, UA., et al. 2017. Eur J Pharmacol. 801: 35-45. PMID: 28274625
  12. The glucagon-like peptide-1 (GLP-1) analog liraglutide attenuates renal fibrosis.  |  Li, YK., et al. 2018. Pharmacol Res. 131: 102-111. PMID: 29530599
  13. Teneligliptin Exerts Antinociceptive Effects in Rat Model of Partial Sciatic Nerve Transection Induced Neuropathic Pain.  |  Kuthati, Y., et al. 2021. Antioxidants (Basel). 10: PMID: 34573072
  14. Mechanisms underlying the prokinetic effects of endogenous glucagon-like peptide-1 in the rat proximal colon.  |  Nakamori, H., et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321: G617-G627. PMID: 34643099
  15. High potency antagonists of the pancreatic glucagon-like peptide-1 receptor.  |  Montrose-Rafizadeh, C., et al. 1997. J Biol Chem. 272: 21201-6. PMID: 9261127

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Product NameCatalog #UNITPriceQtyFAVORITES

Exendin-3 (9-39), 500 µg

sc-364387
500 µg
$428.00
1-800-457-3801
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