Reg Iβ Activators
Reg Iβ, also known as Regenerating Family Member 1 Beta (REG1B), is a protein that is encoded by the REG1B gene in humans. Similar to Reg Iα, it's part of the regenerating gene (REG) family, which was initially identified during studies on pancreatic islet regeneration.Reg Iβ is primarily expressed in the gastrointestinal tract, with the highest levels seen in the stomach and the small intestine. It plays a role in the maintenance and repair of the gastrointestinal tract by promoting cellular proliferation and differentiation and has anti-apoptotic effects that help protect cells from programmed cell death.
Studies have also shown that Reg Iβ is overexpressed in several types of gastrointestinal cancers, including gastric and colorectal cancers, suggesting it might play a role in tumor growth and progression. This overexpression has been associated with cancer aggressiveness and poor prognosis, which indicates that Reg Iβ might serve as a biomarker for these cancers.In addition to its role in cancer, Reg Iβ has been associated with inflammation and immune responses.
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Items 1 to 10 of 19 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate Reg I β, leading to its activation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
A GSK-3 inhibitor, known to stimulate β-cell regeneration, which might indirectly affect Reg Iβ. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $143.00 $194.00 | 1 | |
A GLP-1 receptor agonist, used to increase insulin secretion and beta-cell mass, potentially influencing Reg Iβ. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates cAMP levels, which activates PKA. PKA phosphorylates target proteins, which could include Reg I β, resulting in its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, leading to the activation of calcium-dependent protein kinases that can phosphorylate and activate Reg I β. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Involved in cell differentiation and regeneration; could influence pathways associated with Reg Iβ. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, preventing dephosphorylation and thus maintaining Reg I β in an activated state. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Impacts Wnt signaling pathway, which is involved in various regeneration processes, potentially affecting Reg Iβ. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin initiates the activation of stress-activated protein kinases which may target Reg I β for phosphorylation, thereby activating it. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium storage and activates stress-response kinases, which could phosphorylate and activate Reg I β. | ||||||