Reelin Inhibitors
Reelin inhibitors constitute a diverse group of chemicals with the primary objective of modulating Reelin activity, a crucial protein involved in neuronal migration and synaptic plasticity. Rapamycin, a well-known mTOR inhibitor, indirectly influences Reelin by modulating the mTOR signaling pathway. The inhibition of mTOR by Rapamycin disrupts downstream signaling events, impacting Reelin-related processes crucial for proper brain development. Lithium chloride, a GSK-3 inhibitor, indirectly modulates Reelin by influencing the GSK-3 pathway. GSK-3 is implicated in the phosphorylation and degradation of proteins, including Reelin. Inhibition of GSK-3 by lithium chloride can lead to increased Reelin levels, affecting neuronal migration and synaptic plasticity. DAPT, a γ-secretase inhibitor, indirectly influences Reelin by targeting the Notch signaling pathway. Inhibition of γ-secretase blocks the cleavage of Notch, altering downstream signaling events impacting Reelin expression and function.
Lovastatin, a well-known HMG-CoA reductase inhibitor, indirectly modulates Reelin by affecting the mevalonate pathway. Mevalonate pathway intermediates play a role in the post-translational modification of proteins, including those related to Reelin. Inhibition of HMG-CoA reductase by Lovastatin can influence Reelin function in processes related to neuronal migration and synaptic plasticity. Wortmannin, a PI3-kinase inhibitor, indirectly influences Reelin by targeting the PI3K-Akt signaling pathway. Inhibition of PI3-kinase disrupts downstream signaling events, impacting cellular processes associated with Reelin, including neuronal migration and synaptic plasticity. SB216763, a GSK-3 inhibitor, indirectly modulates Reelin by influencing the GSK-3 pathway, while SU6656, a Src family kinase inhibitor, indirectly influences Reelin by targeting Src family kinases. These kinases regulate downstream signaling pathways related to Reelin, affecting processes such as neuronal migration and synaptic plasticity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly influences Reelin by modulating the mTOR signaling pathway. The inhibition of mTOR impacts downstream signaling cascades, including those related to Reelin, ultimately affecting neuronal migration and synaptic plasticity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride, a GSK-3 inhibitor, indirectly modulates Reelin by influencing the GSK-3 pathway. GSK-3 is involved in the phosphorylation and degradation of key proteins, including Reelin. Inhibition of GSK-3 by lithium chloride can lead to increased Reelin levels, impacting neuronal migration and synaptic function. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT, a γ-secretase inhibitor, indirectly influences Reelin by targeting the Notch signaling pathway. Inhibition of γ-secretase prevents the cleavage of Notch, leading to altered downstream signaling events that can impact Reelin expression and function, particularly in neuronal migration and synaptic plasticity. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin, an HMG-CoA reductase inhibitor, indirectly modulates Reelin by affecting the mevalonate pathway. Mevalonate pathway intermediates are involved in the post-translational modification of proteins, including those related to Reelin. Inhibition of HMG-CoA reductase by lovastatin can influence Reelin function in processes related to neuronal migration and synaptic plasticity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3-kinase inhibitor, indirectly influences Reelin by targeting the PI3K-Akt signaling pathway. Inhibition of PI3-kinase disrupts downstream signaling events, impacting cellular processes associated with Reelin, including neuronal migration and synaptic plasticity. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763, a GSK-3 inhibitor, indirectly modulates Reelin by influencing the GSK-3 pathway. GSK-3 is involved in the phosphorylation and degradation of key proteins, including Reelin. Inhibition of GSK-3 by SB216763 can lead to increased Reelin levels, impacting neuronal migration and synaptic function. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $56.00 $130.00 | 27 | |
SU6656, a Src family kinase inhibitor, indirectly influences Reelin by targeting Src family kinases. These kinases are involved in the regulation of downstream signaling pathways related to Reelin, affecting processes such as neuronal migration and synaptic plasticity. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939, a tankyrase inhibitor, indirectly modulates Reelin by impacting the Wnt signaling pathway. Tankyrase is involved in the regulation of Wnt/β-catenin signaling, which intersects with Reelin signaling pathways. Inhibition of tankyrase by XAV939 can lead to altered Wnt signaling and subsequent effects on Reelin-related cellular processes, including neuronal migration and synaptic plasticity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase (HDAC) inhibitor, indirectly influences Reelin by affecting histone acetylation. HDACs play a role in the epigenetic regulation of gene expression, including genes involved in Reelin signaling. Inhibition of HDACs by Trichostatin A can lead to altered histone acetylation patterns, impacting Reelin expression and function in processes related to neuronal migration and synaptic plasticity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3-kinase inhibitor, indirectly influences Reelin by targeting the PI3K-Akt signaling pathway. Inhibition of PI3-kinase disrupts downstream signaling events, impacting cellular processes associated with Reelin, including neuronal migration and synaptic plasticity. | ||||||