RDM1 Inhibitors
RDM1 inhibitors 5-Azacytidine and Trichostatin A target the epigenetic machinery, potentially altering the expression of genes that control the synthesis and function of RDM1. Methyl methanesulfonate and Etoposide exert their effects through the induction of DNA damage, which can perturb DNA repair pathways that involve RDM1.
Caffeine and Olaparib target specific kinases and enzymes like PARP, which are crucial components of the DNA damage response, a process where RDM1 has a role. Similarly, KU-55933, VE-821, and NU7441 inhibit ATM, ATR, and DNA-PK kinases, respectively, which are pivotal in the signaling cascade of DNA repair mechanisms. Wortmannin's broad inhibition of PI3 kinases can affect signaling pathways that are connected to the cellular processes in which RDM1 is a participant. Additionally, SP600125 and UCN-01 are inhibitors of the JNK signaling pathway and multiple protein kinases, respectively, which can modulate signal transduction pathways and potentially influence RDM1's activity or expression.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor; can alter DNA methylation patterns, which can affect gene expression regulation including genes related to RDM1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor; can change chromatin structure and gene expression, potentially affecting RDM1 expression or function. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
Alkylating agent; can cause DNA damage, potentially affecting DNA repair pathways in which RDM1 is involved. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Topoisomerase II inhibitor; can induce DNA strand breaks, potentially affecting the DNA repair mechanisms associated with RDM1. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Inhibitor of phosphatidylinositol 3-kinase related kinases; can affect DNA damage response pathways, potentially influencing RDM1 activity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitor; can affect DNA repair pathways and potentially the function of RDM1 in DNA damage response. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
ATM kinase inhibitor; can interfere with the cellular response to DNA damage, potentially impacting RDM1's role in this pathway. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
ATR kinase inhibitor; can disrupt the DNA damage response, potentially affecting the function of RDM1 in this process. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
DNA-PK inhibitor; can interfere with the non-homologous end joining pathway, potentially influencing RDM1 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3 kinase inhibitor; can affect various signaling pathways including those related to DNA damage response, potentially impacting RDM1. | ||||||