Molecular structure of Methyl methanesulfonate, CAS Number: 66-27-3
Methyl methanesulfonate (CAS 66-27-3)
See product citations (2)
Alternate Names:
Methanesulfonic acid methyl ester
Application:
Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dna at 7-guanine, 3-guanine and 3-adenine
CAS Number:
66-27-3
Molecular Weight:
110.13
Molecular Formula:
C2H6O3S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dna at 7-guanine, 3-guanine and 3-adenine. Methyl methanesulfonate is an alkylating agent that modifies molecules by reacting with functional groups like amines, carboxylic acids, and thiols. Through the formation of covalent bonds, it alters the structure of molecules, potentially affecting their function and impacting organisms. Induces DNA damage, leading to mutations and cell death.
Methyl methanesulfonate (CAS 66-27-3) References
- The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR. | Brem, R., et al. 2008. DNA Repair (Amst). 7: 849-57. PMID: 18375193
- Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus. | Donovan, P. and Smith, G. 2010. Mutat Res. 699: 55-7. PMID: 20363361
- Low level determinations of methyl methanesulfonate and ethyl methanesulfonate impurities in Lopinavir and Ritonavir Active pharmaceutical ingredients by LC/MS/MS using electrospray ionization. | Kakadiya, PR., et al. 2011. J Pharm Biomed Anal. 55: 379-84. PMID: 21353429
- Brahmarasayana protects against Ethyl methanesulfonate or Methyl methanesulfonate induced chromosomal aberrations in mouse bone marrow cells. | Guruprasad, KP., et al. 2012. BMC Complement Altern Med. 12: 113. PMID: 22853637
- Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway. | Jiang, Y., et al. 2012. Environ Toxicol Pharmacol. 34: 694-704. PMID: 23117069
- Assessment of methyl methanesulfonate using the repeated-dose liver micronucleus assay in young adult rats. | Muto, S., et al. 2015. Mutat Res Genet Toxicol Environ Mutagen. 780-781: 107-10. PMID: 25892629
- Evaluation of methyl methanesulfonate, 2,6-diaminotoluene and 5-fluorouracil: Part of the Japanese center for the validation of alternative methods (JaCVAM) international validation study of the in vivo rat alkaline comet assay. | Plappert-Helbig, U., et al. 2015. Mutat Res Genet Toxicol Environ Mutagen. 786-788: 120-4. PMID: 26212301
- Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. | Jiang, Y., et al. 2016. Tumour Biol. 37: 3785-95. PMID: 26472723
- Depletion of Paraspeckle Protein 1 Enhances Methyl Methanesulfonate-Induced Apoptosis through Mitotic Catastrophe. | Gao, X., et al. 2016. PLoS One. 11: e0146952. PMID: 26785254
- Induction of innate immune gene expression following methyl methanesulfonate-induced DNA damage in sea urchins. | Reinardy, HC., et al. 2016. Biol Lett. 12: 20151057. PMID: 26911343
- Feedback regulation of methyl methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatin. | Lv, J., et al. 2017. Tumour Biol. 39: 1010428317694307. PMID: 28347251
- The response to the DNA damaging agent methyl methanesulfonate in a fungal plant pathogen. | Milo-Cochavi, S., et al. 2019. Fungal Biol. 123: 408-422. PMID: 31053330
- Activation of a Mitogen-Activated Protein Kinase Hog1 by DNA Damaging Agent Methyl Methanesulfonate in Yeast. | Huang, S., et al. 2020. Front Mol Biosci. 7: 581095. PMID: 33425986
- Deletion of Plasmodium falciparum ubc13 increases parasite sensitivity to the mutagen, methyl methanesulfonate and dihydroartemisinin. | Maneekesorn, S., et al. 2021. Sci Rep. 11: 21791. PMID: 34750454
- Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate. | Feng, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35886903
Inhibitor of:
Arylsulfatase F, Arylsulfatase K, ASCC2, GAL4 (DBD), Hbb-b2, Lex A, MSH, PRX VI, Rad55, RDM1, RecA, and XPF.Activator of:
53BP1, Ape2, APLF, Aprataxin, APRIN, ATAD5, Atm, ATR, ATRX, Bck2, Bir1, BLM hydrolase, BRAF35, Bub2, C15orf41, C19orf57, C20orf196, CAF-1 p60, CCDC6, Cdc13, CED-7, CNF1, CNF2, Crt1, Csprs, cyclin δ-3, Dclre1c, DDI1, DEM1, DHH1, DinB, Dmc1, DNA pol ζ, DYDC1, EF-Ts, EndoV, EST-1, EXOD1, FAAP24, FANCA, FLJ20433, Fob1, GADD 45α, Gal11, GATA-2, GEN1, H2al3, Histone H2A.J, HORMAD1, HPV18 E6, HRP-1, Hus1B, JIP-2, KIAA1530, Ku, Ku-86, LIN-3, MAD2B, MBD4, Mcm1, MDC1, Mkk2, MLH3, MPK-1, NFRκB, NSE2, NTH1, OGG2, OR7E24, p53R2, pADPr, PARP-10, PARP-15, PARP-8, PGBD3, PICH_Ercc6l, POL H, Pol2, POLDIP2, Psf2, Rad23, Rad24, Rad26L, Rad51B, Rad51D, Rad52, Rad53, Rad57, Rad59, Rad9, Rad9B, RECA-1, RecQL4, REV1, Rev3, Rga1, RGPD6, RMI1, RMI2, RNF168, RNF169, RPA 34 kDa subunit, Rsp5, RuvA, RuvC, Salmonella B, Sgs1, Sho1, Sin4p, SPATA22, Srs2, Ste20, Sum1, TEX11, TFIIH 2C, TSC-22, and Tup1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methyl methanesulfonate, 5 g | sc-250376 | 5 g | $55.00 | |||
Methyl methanesulfonate, 25 g | sc-250376A | 25 g | $130.00 |