RBMY1A1 Inhibitors
Chemical inhibitors of RBMY1A1 function through diverse biochemical mechanisms to disrupt the processes essential for its role in spermatogenesis. Paclitaxel, a well-known microtubule stabilizer, can inhibit RBMY1A1 indirectly by halting the cell division that is crucial for the production of sperm cells. Similarly, Etoposide's ability to inhibit DNA topoisomerase II results in DNA damage and cell cycle arrest, which subsequently hinders the cell division necessary for RBMY1A1 to carry out its function in germ cell development. Withaferin A targets the splicing factors and nuclear speckles, disrupting the correct splicing of pre-mRNA, a process where RBMY1A1 is actively involved. Inhibiting this pathway can impede RBMY1A1's ability to contribute to spermatogenesis. Moreover, Plumbagin and Curcumin exert their influence by modulating signaling pathways, with Plumbagin affecting the STAT3 signaling and Curcumin inhibiting the NF-κB pathway, both of which are crucial for cell survival and proliferation, thereby affecting the RBMY1A1 environment.
The second category of inhibitors operates by influencing gene expression and cellular signaling pathways involved in cell growth and differentiation. Resveratrol's inhibition of the MAPK pathway can indirectly impede RBMY1A1's role in germ cell differentiation. Histone deacetylase inhibitors such as Trichostatin A and Vorinostat can alter chromatin structure and gene expression, influencing the expression of genes necessary for germ cell development and potentially affecting RBMY1A1's function in this process. Disulfiram's proteasome inhibition could lead to an accumulation of proteins, including RBMY1A1, which might disrupt normal protein turnover and processing, leading to a functional inhibition of RBMY1A1. Genistein, as a tyrosine kinase inhibitor, disrupts cellular pathways, potentially affecting those that are essential for the role of RBMY1A1 in spermatogenesis. Lastly, Rapamycin's inhibition of the mTOR pathway, which is vital for cell growth and proliferation, can disrupt the proliferation and development of germ cells, thus indirectly affecting the function of RBMY1A1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and as a result, can inhibit cell division. Since RBMY1A1 is involved in spermatogenesis, a process of cell division, paclitaxel can indirectly inhibit the function of RBMY1A1 by preventing the cell division necessary for spermatogenesis. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A is known to disrupt splicing factors and nuclear speckles. Given that RBMY1A1 is a RNA-binding protein and involved in splicing, Withaferin A can inhibit RBMY1A1 by disrupting the splicing machinery it interacts with. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, leading to DNA damage and cell cycle arrest. RBMY1A1, being involved in germ cell development, would be functionally inhibited in a scenario where DNA replication and cell division are compromised. | ||||||
Plumbagin | 481-42-5 | sc-253283 sc-253283A | 100 mg 250 mg | $51.00 $61.00 | 6 | |
Plumbagin has been shown to inhibit the STAT3 signaling pathway. Since RBMY1A1 is associated with male germ cell development and STAT3 is involved in cell growth and apoptosis, plumbagin can indirectly inhibit RBMY1A1 function by suppressing cellular pathways critical for germ cell development. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit the NF-κB pathway, which is involved in the regulation of cell survival and proliferation. RBMY1A1 is a protein that is important for spermatogenesis, and by inhibiting NF-κB, curcumin can indirectly inhibit the environment necessary for RBMY1A1 to function in germ cell development. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to inhibit the activation of the MAPK pathway, which is important in cell growth and differentiation. RBMY1A1 plays a role in male germ cell differentiation, and hence, resveratrol can indirectly inhibit RBMY1A1 by inhibiting the MAPK pathway. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor and can alter chromatin structure and gene expression. By changing the expression of genes necessary for germ cell development, it can indirectly inhibit the function of RBMY1A1, which is essential for spermatogenesis. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, similar to Trichostatin A, inhibits histone deacetylases. This can lead to an altered gene expression profile affecting spermatogenesis, and thereby, functionally inhibiting RBMY1A1 which is required for this process. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit the proteasome, which is responsible for protein degradation. RBMY1A1, being a protein, may be stabilized by proteasome inhibition, which paradoxically could result in functional inhibition due to the disruption of normal protein turnover and processing. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can inhibit multiple cellular pathways. By inhibiting tyrosine kinases that are potentially involved in the signaling pathways necessary for spermatogenesis, genistein can indirectly inhibit the functional role of RBMY1A1 in this process. | ||||||