Molecular structure of Plumbagin, CAS Number: 481-42-5
Plumbagin (CAS 481-42-5)
See product citations (6)
Alternate Names:
5-Hydroxy-2-methyl-1,4-naphthoquinone
Application:
Plumbagin is a potent anticancer agent
CAS Number:
481-42-5
Molecular Weight:
188.18
Molecular Formula:
C11H8O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Plumbagin is a naturally occurring naphthoquinone compound that has been the subject of considerable research interest due to its various biological activities. In research environments, plumbagin is often studied for its role in cellular mechanisms such as apoptosis and cell cycle regulation. Researchers also explore its effects on oxidative stress pathways and its potential as a signaling molecule that can influence the activity of transcription factors. Studies have shown that plumbagin can affect the expression of genes involved in oxidative stress response and could be used in models to understand the molecular mechanisms underlying these processes. Additionally, it is frequently utilized in the study of plant-derived bioactive compounds, where it serves as a model for understanding the interaction between such molecules and cellular targets.
Plumbagin (CAS 481-42-5) References
- Plumbagin and Its Role in Chronic Diseases. | Panichayupakaranant, P. and Ahmad, MI. 2016. Adv Exp Med Biol. 929: 229-246. PMID: 27771927
- Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review. | Liu, Y., et al. 2017. Am J Chin Med. 45: 423-441. PMID: 28359198
- Biotechnological Approaches for the Production of Pharmaceutically Important Compound: Plumbagin. | Roy, A. and Bharadvaja, N. 2018. Curr Pharm Biotechnol. 19: 372-381. PMID: 29956626
- Emerging role of plumbagin: Cytotoxic potential and pharmaceutical relevance towards cancer therapy. | Tripathi, SK., et al. 2019. Food Chem Toxicol. 125: 566-582. PMID: 30685472
- Plumbagin: A Potential Anti-cancer Compound. | Roy, A. 2021. Mini Rev Med Chem. 21: 731-737. PMID: 33200707
- Plumbagin induces testicular damage via mitochondrial-dependent cell death. | Bello, IJ., et al. 2021. Chem Biol Interact. 347: 109582. PMID: 34302802
- The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts. | Yadav, AM., et al. 2022. Biol Chem. 403: 211-229. PMID: 34882360
- Plumbagin: A Potential Candidate for Future Research and Development. | Thakor, N. and Janathia, B. 2022. Curr Pharm Biotechnol. 23: 1800-1812. PMID: 34967293
- Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats. | Kumar Arora, M., et al. 2022. Molecules. 27: PMID: 35335195
- Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth. | Zhan, S., et al. 2022. Br J Cancer. 127: 364-376. PMID: 35396498
- Plumbagin ameliorates bile duct ligation-induced cholestatic liver injury in rats. | Pan, PH., et al. 2022. Biomed Pharmacother. 151: 113133. PMID: 35594710
- Plumbagin relieves rheumatoid arthritis through nuclear factor kappa-B (NF-κB) pathway. | Shu, C., et al. 2022. Bioengineered. 13: 13632-13642. PMID: 35653787
- Nano co-delivery of Plumbagin and Dihydrotanshinone I reverses immunosuppressive TME of liver cancer. | Han, S., et al. 2022. J Control Release. 348: 250-263. PMID: 35660631
- Structural Insights and Pharmaceutical Relevance of Plumbagin in Parasitic Disorders: A Comprehensive Review. | Singh, AP. and Sharma, A. 2022. Recent Adv Antiinfect Drug Discov. 17: 187-198. PMID: 36065920
Inhibitor of:
β-1,3-Gal-TL, 5330437I02Rik, ATP10A, BTG4, colipase, CXCR-4, CYB561D1, CYB5D1, CYB5R2, DDX35, DGCR8, EG636741, Fos B, GCN5, glutathione S-transferase mu (GSTM), Gm15070, gp91phox, GSTCD, GSTO2, Gstp2, H2-M11, hnRNP M, hnRNP Q, Intelectin-b, IQCF2, LOC439994, M13 filamentous phage, Mox1, MsrB3, NKHC1, Nkx-2.4, NOXA1, NOXO1, NOXRED1, NQO1, Olr542, Olr556, Olr601, p40-phox, RBMY1A1, RNase 4, Sciellin, SERCA1, SHOX2A, Sm F, TFIIIC35, Tns3, U2AF35, Vmn2r26, ZDHHC25, ZFOC1, ZNF12, ZNF469, and ZNF862.Activator of:
aminopeptidase-I, HSP 47, HSPB9, MPV17L, Nanos2, Sptrx-1, U2 snRNP A, and ZFP56d3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Plumbagin, 100 mg | sc-253283 | 100 mg | $51.00 | |||
Plumbagin, 250 mg | sc-253283A | 250 mg | $61.00 |