RBM46 Activators
RBM46 activators are a category of chemical compounds that target the regulatory protein known as RBM46. RBM46 is part of a broader class of proteins called RNA-binding proteins, which play crucial roles in post-transcriptional regulation of gene expression. This includes processes such as alternative splicing, mRNA transport, stability, and translation. The specific functions of RBM46 within these processes, however, can be quite complex as it involves the recognition and binding to particular RNA sequences or structures, thereby influencing the fate of the RNA molecules. Activators of RBM46 are designed to modulate this protein's activity, potentially affecting the various pathways in which RBM46 is involved.
The chemical structure of RBM46 activators can vary widely, but they share the common characteristic of being able to interact with the RBM46 protein in a way that enhances its natural function. This interaction might involve binding to the protein at specific domains that are crucial for its RNA-binding capacity, or they might affect the protein's conformation, stability, or its interactions with other molecules within the cell. As with many such activators, the precise mechanisms by which they exert their effects can be multi-faceted and may involve direct or indirect modulation of the protein's activity. Research into RBM46 and its activators often requires a multidisciplinary approach, combining synthetic chemistry for the development of the activator molecules, biochemistry and molecular biology for understanding the protein's function, and biophysical techniques to elucidate the nature of the protein-activator interaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate specific substrates resulting in the activation of RBM46 by facilitating its participation in RNA processing events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC phosphorylation can lead to changes in splicing factor dynamics and localization, indirectly enhancing RBM46's role in RNA splicing. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a tyrosine kinase inhibitor that can modulate signaling pathways involving phosphorylation. By inhibiting competitive pathways, it may enhance the phosphorylation status of RBM46, thereby promoting its activity in mRNA processing. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation of proteins involved in mRNA processing, potentially increasing RBM46's activity in these pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. This can influence RBM46 activity by affecting the phosphorylation state of proteins in RNA binding and processing complexes. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels within the cell. This can indirectly enhance the activity of RBM46 by maintaining its phosphorylation state necessary for its RNA binding function. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine has been shown to modulate RNA binding protein activity through interactions with RNA. It may enhance RBM46 activity by stabilizing RNA-RBM46 complexes, thus promoting efficient RNA processing. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs). This activation can lead to alterations in RNA splicing factor dynamics, possibly enhancing the functional activity of RBM46. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a general inhibitor of tyrosine phosphatases, which can lead to increased tyrosine phosphorylation within cells. Enhanced phosphorylation may indirectly activate RBM46 by affecting associated signaling pathways. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $126.00 $210.00 $488.00 | 19 | |
K-252a is an inhibitor of protein kinase C, which can modulate the phosphorylation state of various proteins. By altering signaling pathways, K-252a may enhance the activity of RBM46 in RNA processing. | ||||||