PUSL1 Activators
PUSL1 Activators represent a specific subset of chemical compounds that have garnered attention in the field of molecular biology and biochemistry due to their role in modulating the activity of the PUSL1 gene. PUSL1, also known as Pseudouridylate Synthase-Like 1, is a protein-coding gene found in humans. While the precise biological functions of PUSL1 are still the subject of ongoing research, this gene is known to encode a protein that is part of the pseudouridine synthase family. Pseudouridine is a modified RNA base that plays a crucial role in the stability and function of various RNA molecules, including transfer RNA (tRNA) and ribosomal RNA (rRNA). PUSL1 Activators, as the name suggests, are a group of molecules that enhance or promote the expression and function of the PUSL1 gene, leading to increased activity of the associated protein.
The mechanism of action of PUSL1 Activators typically involves their interaction with specific regulatory elements within the PUSL1 gene's promoter region or enhancer sequences. This interaction can result in the upregulation of gene transcription and the subsequent synthesis of the PUSL1 protein. The PUSL1 protein is involved in pseudouridylation, a post-transcriptional modification of RNA molecules, and may contribute to the structural stability and functionality of these molecules. As researchers continue to explore the functions and downstream effects of PUSL1 activation, the development and refinement of PUSL1 Activators hold promise for advancing our understanding of RNA biology and its implications in various scientific and molecular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a nucleoside analog of cytidine, azacitidine may interfere with RNA methylation patterns, potentially upregulating PUSL1 expression as the cell attempts to compensate for altered RNA modification landscapes. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
This compound intercalates into DNA, inhibiting transcription. This stress may lead to a compensatory increase in RNA modification enzymes, including PUSL1, as the cell tries to maintain RNA function. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Known to inhibit bacterial RNA polymerase, rifampicin might indirectly affect eukaryotic RNA synthesis and processing pathways, potentially influencing PUSL1 expression as part of a broader stress response. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
As an autophagy inhibitor and anti-malarial, chloroquine can affect cellular stress responses and might influence the expression of genes like PUSL1 involved in RNA stability and processing. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
This topoisomerase inhibitor induces DNA damage and can lead to altered gene expression patterns, possibly upregulating PUSL1 as part of the DNA damage response and the need for RNA repair and modification. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
As a selective estrogen receptor modulator, tamoxifen influences gene expression through estrogen receptor pathways, which could include genes like PUSL1 involved in RNA processing. | ||||||
Aminophylline | 317-34-0 | sc-252368 | 25 g | $37.00 | ||
By inhibiting phosphodiesterases and increasing cAMP levels, aminophylline could modulate transcription factor activity, potentially leading to increased PUSL1 expression as part of altered cell signaling. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Known to inhibit aldehyde dehydrogenase, disulfiram can also affect other cellular processes, potentially inducing stress responses that upregulate RNA modification enzymes like PUSL1. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
As a dihydrofolate reductase inhibitor, methotrexate disrupts nucleotide synthesis, which could lead to compensatory mechanisms involving RNA modification enzymes, including PUSL1. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
As an antifungal with potential effects on selenoproteins, selenium sulfide might influence cellular pathways involving RNA processing, potentially affecting PUSL1 expression. | ||||||