PTRH2 Activators
PTRH2 activators comprise a spectrum of chemical compounds that indirectly enhance the functional activity of PTRH2 by modulating various cellular signaling pathways. Forskolin, through the elevation of cAMP levels, indirectly augments PTRH2's activity by activating PKA, which may lead to phosphorylation events that enhance PTRH2's role in maintaining mitochondrial integrity. Similarly, Epigallocatechin gallate (EGCG), by inhibiting competitive protein kinases, could shift the equilibrium of cellular signaling, thereby potentially increasing the activity of PTRH2 in apoptotic regulation. Sphingosine-1-phosphate and Thapsigargin both influence lipid and calcium signaling, respectively, which are pivotal for the mitochondrial functions in which PTRH2 is implicated, thereby potentiating its activity. PMA, as a PKC activator, and the PI3K inhibitors LY294002 and Wortmannin, contribute to the activation of PTRH2 by modulating signaling pathways that impact mitochondrial apoptosis and cellular stress responses.
The role of PTRH2 in mitochondrial health is further supported by compounds that interact with the MAPK signaling pathway, such as SB203580 and U0126, which inhibit p38 and MEK1/2, respectively, shifting cellular signaling to favor pathways that enhance PTRH2's activity. Genisteein, through its tyrosine kinase inhibition, reduces competition from tyrosine kinase signaling, potentially amplifying PTRH2's role in cell survival pathways. A23187, by increasing intracellular calcium levels, activates calcium-dependent signaling crucial for mitochondrial function, indirectly enhancing PTRH2's activity. Staurosporine, while broadly inhibiting protein kinases, may selectively activate PTRH2 pathways by alleviating inhibition from specific kinases on processes associated with mitochondrial apoptosis. Collectively, these activators, through targeted effects on distinct cellular signaling pathways, facilitate the functional enhancement of PTRH2 without the need for upregulating its expression or directly stimulating the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which can phosphorylate specific substrates, potentially altering the conformation and enhancing the activity of PTRH2 involved in mitochondrial integrity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a known inhibitor of various protein kinases. By inhibiting competitive kinases, EGCG could shift the balance of cellular signaling, indirectly increasing PTRH2 activity related to apoptosis regulation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule activates sphingosine kinase, leading to a cascade that can affect mitochondrial function. Since PTRH2 is implicated in mitochondrial integrity, this cascade could enhance PTRH2's protective role. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts the endoplasmic reticulum calcium stores, potentially affecting calcium-dependent proteases that might interact with PTRH2, leading to an indirect increase in PTRH2 functional activity related to proteostasis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which can phosphorylate various proteins. PKC activation might lead to phosphorylation events that enhance PTRH2's activity in cellular stress responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which could alter the PI3K/AKT pathway. Modulating this pathway might enhance the role of PTRH2 in mitochondrial apoptotic processes by shifting cellular survival signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that, like LY294002, can alter the PI3K/AKT pathway, potentially enhancing PTRH2's role in apoptosis through modulation of downstream mitochondrial signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK can affect cellular stress responses, potentially leading to enhanced activity of PTRH2 in mitochondrial health maintenance. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, which could potentiate PTRH2's activity by reducing competition from tyrosine kinase signaling, potentially enhancing PTRH2's role in cell survival pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can modulate various calcium-dependent pathways, which might enhance the activity of PTRH2 in mitochondrial signaling. | ||||||