PRR15 Activators
PRR15 activators encompass a diverse array of chemical compounds that influence signaling pathways and cellular processes to enhance the functional activity of PRR15. Retinoic acid, through its interaction with retinoic acid receptors, enhances the expression of PRR15 by modulating gene expression linked to cellular differentiation and growth. Similarly, Dibutyryl cyclic-AMP and Isoproterenol increase intracellular cAMP, which activates PKA, leading to the phosphorylation of transcription factors and other proteins that may elevate PRR15 activity. Forskolin amplifies this effect by directly stimulating adenylyl cyclase, further boosting cAMP levels and PKA activity. PMA, as a PKC activator, and EGF, through the activation of the EGF receptor and subsequent MAPK/ERK pathway activation, catalyze downstream events that can culminate in the upregulation of PRR15. Insulin-triggered PI3K/AKT signaling and Ionomycin-induced calcium-dependent pathways also contribute to the enhancement of PRR15, either by influencing cell metabolism and growth or by modifying protein interactions within PRR15-related pathways.
Furthermore, Lithium chloride's inhibition of GSK-3 may indirectly activate PRR15 by affecting Wnt signaling, a pathway potentially connected to PRR15 activity. Epigenetic modifiers such as Sodium butyrate andTrichostatin A operate by remodeling chromatin, thereby facilitating transcriptional activation of PRR15 and other genes. These histone deacetylase inhibitors open up the chromatin structure, creating a more accessible environment for transcription factors to promote PRR15 expression. Zinc sulfate, with its role in enhancing the function of DNA-binding proteins with zinc finger motifs, can similarly boost PRR15 activity by improving transcriptional regulation. Collectively, these chemical activators, by targeting distinct but interrelated signaling pathways and cellular processes, synergistically augment the functional activity of PRR15 without the need for direct activation or elevated expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts on retinoic acid receptors, which subsequently regulate gene expression, including the expression of PRR15. Activation of these receptors leads to differentiation and growth effects that enhance the functional activity of PRR15. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cyclic-AMP is a cell-permeable cAMP analog that activates protein kinase A (PKA). PKA phosphorylation can lead to changes in protein-protein interactions and the activity of transcription factors that may enhance the expression and activity of PRR15. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as a potent activator of protein kinase C (PKC), which can phosphorylate transcription factors or other proteins that are involved in the signaling pathways modulating PRR15 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, resulting in increased levels of cAMP and subsequent activation of PKA. PKA activation can influence the phosphorylation status and activity of proteins interacting with PRR15. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor activation stimulates the PI3K/AKT signaling pathway, which can lead to the activation of downstream proteins that influence PRR15 activity through effects on cell growth and metabolism. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent kinases and phosphatases that could enhance the activity of PRR15 by modulating proteins within PRR15-related signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, thereby activating PKA and potentially enhancing PRR15 activity through PKA-mediated phosphorylation of associated proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), which could lead to the stabilization and activation of proteins within Wnt signaling pathways that are known to influence PRR15 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor which can lead to chromatin remodeling and an increase in accessible DNA for transcription, possibly enhancing the expression and function of PRR15 by this epigenetic modification. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, another histone deacetylase inhibitor, may enhance PRR15 activity by increasing gene expression through epigenetic changes, leading to an open chromatin state conducive to transcription factor binding and gene expression. | ||||||