PRPS2 Inhibitors
PRPS2 inhibitors belong to a specific chemical class designed to target and modulate the activity of the enzyme phosphoribosyl pyrophosphate synthetase 2 (PRPS2). This enzyme plays a pivotal role in the de novo biosynthesis of purine nucleotides, crucial components of DNA and RNA. Purine nucleotides are essential for various cellular processes, including DNA replication, RNA synthesis, and energy transfer. PRPS2 catalyzes the conversion of ribose-5-phosphate to phosphoribosyl pyrophosphate (PRPP), a key precursor in the purine biosynthetic pathway. By inhibiting PRPS2, these compounds disrupt the synthesis of PRPP, leading to downstream effects on purine nucleotide production.
The mechanism of PRPS2 inhibitors involves interference with the enzymatic activity of PRPS2, typically through competitive binding to its active site or by altering its conformation. This inhibition hampers the normal flow of purine nucleotide synthesis, potentially impacting cellular proliferation and nucleic acid metabolism. The design and development of PRPS2 inhibitors aim to explore their potential as research tools to dissect the intricate biochemical pathways associated with purine nucleotide biosynthesis. Understanding the intricate regulation of these pathways and the role of PRPS2 provides valuable insights into cellular physiology and may open avenues for future investigations in basic science and molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Inhibits dihydrofolate reductase, leading to reduced purine synthesis, therefore can decrease the substrate availability for PRPS2. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $71.00 $102.00 | ||
Purine analog that can be incorporated into nucleic acids, can deplete purine pools and indirectly inhibit the activity of PRPS2. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Prodrug for 6-mercaptopurine, has similar effects once metabolized, can indirectly decrease PRPS2 activity through feedback inhibition. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Xanthine oxidase inhibitor, increases hypoxanthine and xanthine, which can feedback inhibit PRPS2. | ||||||
Oxipurinol | 2465-59-0 | sc-208138 sc-208138A | 100 mg 500 mg | $218.00 $744.00 | 1 | |
The active metabolite of Allopurinol, has a similar mechanism of action and can indirectly inhibit PRPS2 activity. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, can lead to decreased guanine nucleotides and indirectly influence PRPS2 activity. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Inhibits inosine monophosphate dehydrogenase, which can reduce GTP levels and indirectly affect PRPS2 activity. | ||||||
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $39.00 $92.00 | 2 | |
Inhibits xanthine oxidase, can increase levels of hypoxanthine and xanthine, leading to indirect inhibition of PRPS2 through feedback mechanisms. | ||||||
Tiazofurin | 60084-10-8 | sc-475805 | 5 mg | $440.00 | ||
Inhibits inosine monophosphate dehydrogenase, can result in altered nucleotide levels and indirectly affect PRPS2 activity. | ||||||
Febuxostat | 144060-53-7 | sc-207680 | 10 mg | $168.00 | 3 | |
Inhibits xanthine oxidase, which can indirectly reduce PRPS2 activity by increasing xanthine and hypoxanthine that feedback inhibit PRPS2. | ||||||