Febuxostat (CAS 144060-53-7)
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Febuxostat serves as an important compound in the field of enzymology and biochemical research, where it is used to study the inhibition of xanthine oxidase, an enzyme involved in purine metabolism. This inhibition is significant in understanding the biochemical pathways that lead to the overproduction of uric acid. In research applications, febuxostat is utilized to explore the enzyme′s active site and to investigate the structural requirements for inhibitor binding, which can have implications in the design of new compounds with similar or improved inhibitory properties. Additionally, febuxostat is used as a tool in the study of oxidative stress and free radical generation, processes in which xanthine oxidase has a significant role. Understanding these processes is helpful for the investigation of how cellular damage occurs in various stress-related conditions.
Febuxostat (CAS 144060-53-7) References
- Febuxostat for the treatment of hyperuricaemia in gout. | Robinson, PC. and Dalbeth, N. 2018. Expert Opin Pharmacother. 19: 1289-1299. PMID: 30024787
- Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis. | Kondo, M., et al. 2019. Am J Hypertens. 32: 249-256. PMID: 30351343
- Febuxostat administration for the prevention of tumour lysis syndrome: A meta-analysis. | Bellos, I., et al. 2019. J Clin Pharm Ther. 44: 525-533. PMID: 30972811
- Febuxostat ameliorates methotrexate-induced lung damage. | Zaki, SM., et al. 2021. Folia Morphol (Warsz). 80: 392-402. PMID: 32644182
- Febuxostat Attenuates the Induction of Vascular Cell Adhesion Protein 1 by TNF-α in Human Umbilical Vein Endothelial Cells. | Suzuki, Y., et al. 2021. Pharmacology. 106: 218-224. PMID: 33176323
- Febuxostat Inhibits MPP+-Induced Inflammatory Response Through Inhibiting the JNK/NF-κB Pathway in Astrocytes. | Yan, W., et al. 2021. Neurotox Res. 39: 566-574. PMID: 33443645
- Febuxostat Attenuates the Progression of Periodontitis in Rats. | Nessa, N., et al. 2021. Pharmacology. 106: 294-304. PMID: 33735887
- Febuxostat ameliorates high salt intake-induced hypertension and renal damage in Dahl salt-sensitive rats. | Miura, T., et al. 2022. J Hypertens. 40: 327-337. PMID: 34495901
- The major cardiovascular events of febuxostat versus allopurinol in treating gout or asymptomatic hyperuricemia: a systematic review and meta-analysis. | Wang, M., et al. 2021. Ann Palliat Med. 10: 10327-10337. PMID: 34498481
- Febuxostat, an inhibitor of xanthine oxidase, ameliorates ionizing radiation-induced lung injury by suppressing caspase-3, oxidative stress and NF-κB. | Raeispour, M., et al. 2022. Drug Chem Toxicol. 45: 2586-2593. PMID: 34538151
- Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug-drug interactions with rivaroxaban. | Tang, LWT., et al. 2022. Biopharm Drug Dispos. 43: 57-65. PMID: 35088420
- Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. | Zhu, Y., et al. 2022. Toxicol Sci. 189: 216-224. PMID: 35866629
- Febuxostat Protects Human Aortic Valve Endothelial Cells From Oxidized Low-density Lipoprotein-Induced Injury and Monocyte Attachment. | Liang, X., et al. 2022. J Cardiovasc Pharmacol. 80: 861-868. PMID: 35881896
- Novel Antibacterial Activity of Febuxostat, an FDA-Approved Antigout Drug against Mycobacterium tuberculosis Infection. | Kim, LH., et al. 2022. Antimicrob Agents Chemother. 66: e0076222. PMID: 36040172
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Febuxostat, 10 mg | sc-207680 | 10 mg | $168.00 |