PRPS1 Inhibitors
Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) plays a crucial role in the purine and pyrimidine nucleotide biosynthetic pathways. PRPS1 is an enzyme responsible for the synthesis of phosphoribosyl pyrophosphate (PRPP), a key precursor in the formation of purine and pyrimidine nucleotides. The significance of PRPS1 arises from its central position in nucleotide biosynthesis, ensuring a consistent supply of nucleotides necessary for various cellular processes, such as DNA replication, RNA transcription, and ATP-mediated energy transfer. Given its foundational role, any modulation of PRPS1's activity can significantly influence the overall nucleotide pool inside the cell.
PRPS1 inhibitors encompass a diverse range of chemical compounds that impede the normal functioning of the PRPS1 enzyme. The mechanism of action of many of these inhibitors often revolves around competition with the natural substrates or products of PRPS1, thereby affecting its enzymatic activity. Some inhibitors act by directly binding to the enzyme's active or allosteric sites, inducing conformational changes that diminish the enzyme's ability to synthesize PRPP. Others, by contrast, are analogs of native substrates and, when metabolized within the cell, interfere with the natural substrates' interaction with the enzyme. This interference can result in reduced synthesis of PRPP and, consequently, a decrease in the production of purine and pyrimidine nucleotides. Furthermore, the availability of these inhibitors has been crucial in advancing our understanding of nucleotide metabolism and the pivotal role PRPS1 plays in this intricate biochemical process.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $104.00 $416.00 $655.00 $1301.00 | 10 | |
Acivicin is a glutamine analogue that inhibits PRPS1 by competing with the substrate phosphoribosyl pyrophosphate. It interrupts nucleotide synthesis, thereby affecting cell proliferation. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
Once inside the cell, 6-thioguanine is converted into the active thio-GMP, which inhibits de novo purine synthesis by competing with the native substrates of PRPS1. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid (MPA) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH). Although not a direct inhibitor of PRPS1, it reduces the pool of IMP, affecting PRPS1 activity indirectly. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin is a guanosine analogue that, once phosphorylated, can inhibit PRPS1 by competition with the native substrates, affecting nucleotide biosynthesis. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine, when inside cells, gets converted to AMP. High levels of AMP can indirectly inhibit PRPS1 by feedback inhibition, impacting purine nucleotide synthesis. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
Allopurinol is mainly an xanthine oxidase inhibitor. It gets metabolized to oxypurinol, which can indirectly affect PRPS1 activity by influencing purine salvage pathways. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, impacting the folate cycle. This indirectly affects the availability of one-carbon units required for purine synthesis, influencing PRPS1. | ||||||
Tiazofurin | 60084-10-8 | sc-475805 | 5 mg | $449.00 | ||
Tiazofurin gets converted into thiazole-4-carboxamide adenine dinucleotide (TAD), which inhibits IMP dehydrogenase. Though not a direct PRPS1 inhibitor, it affects purine metabolism. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil affects thymidylate synthase, reducing dTMP synthesis. This disruption in pyrimidine synthesis can indirectly impact purine synthesis and PRPS1 activity. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Prodrug of 6-mercaptopurine. Once metabolized, it acts similarly to 6-mercaptopurine, inhibiting PRPS1 by its active metabolites that compete with natural PRPS1 substrates. | ||||||