Molecular structure of Acivicin, CAS Number: 42228-92-2
Acivicin (CAS 42228-92-2)
See product citations (10)
Alternate Names:
αS-amino-3-chloro-4,5S-dihydro-5-isoxazoleacetic acid; (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid; [S-(R*,R*)]-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid; AT 125; Antibiotic AT 125; NSC 163501; U 42126; (+)-Acivicin
Application:
Acivicin is an inhibitor of GGT used for solid tumor research
CAS Number:
42228-92-2
Purity:
≥97%
Molecular Weight:
178.57
Molecular Formula:
C5H7ClN2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acivicin is an antineoplastic antibiotic believed to act by interfering with glutamine metabolism which has been researched in a variety of solid tumor samples. Acivicin is an irreversible inhibitor of GGT (gamma-glutamyl transpeptidase) ID50 = 0.54 mM. Additionally, it inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4 and the bioactivation and release of nitric oxide from GSNO6. Also, studies show anti-tumor and anti-metastatic activity and blocks H. Pylori GGT-induced T-cell inhibition.
Acivicin (CAS 42228-92-2) References
- Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice. | Townsend, DM. and Hanigan, MH. 2002. J Pharmacol Exp Ther. 300: 142-8. PMID: 11752109
- gamma-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liver. | Obrador, E., et al. 2002. Hepatology. 35: 74-81. PMID: 11786961
- Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma. | Ruoso, P. and Hedley, DW. 2004. Cancer Chemother Pharmacol. 54: 49-56. PMID: 15034755
- Effects of probenecid and acivicin on potassium dichromate-induced acute nephrotoxicity in mice. | De Ceaurriz, J. and Ban, M. 1991. Toxicol Lett. 59: 139-45. PMID: 1684453
- Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase. | Schmees, C., et al. 2007. Gastroenterology. 132: 1820-33. PMID: 17484877
- Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture. | Williams, MG., et al. 1990. Cancer Res. 50: 5475-80. PMID: 2386952
- Distribution of gamma-glutamyl transpeptidase in the mouse epididymis and its response to acivicin. | Agrawal, YP., et al. 1989. J Reprod Fertil. 86: 185-93. PMID: 2569039
- Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells. | Kemp, AJ., et al. 1986. J Biol Chem. 261: 14891-5. PMID: 3771555
- The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). | Allen, L., et al. 1980. Res Commun Chem Pathol Pharmacol. 27: 175-82. PMID: 6102405
- Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency. | Griffith, OW. and Meister, A. 1980. Proc Natl Acad Sci U S A. 77: 3384-7. PMID: 6106190
- Effects of acivicin and dipyridamole on hepatoma 3924A cells. | Zhen, YS., et al. 1983. Cancer Res. 43: 1616-9. PMID: 6831407
- Biochemical pharmacology of acivicin in rat hepatoma cells. | Lui, MS., et al. 1982. Biochem Pharmacol. 31: 3469-73. PMID: 7150366
- Sex- and age-related mouse toxicity and disposition of the amino acid antitumor agent, acivicin. | McGovren, JP., et al. 1981. J Pharmacol Exp Ther. 216: 433-40. PMID: 7205622
- S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase. | Hogg, N., et al. 1997. Biochem J. 323 (Pt 2): 477-81. PMID: 9163341
Inhibitor of:
γ-GCSc, γ-GCSm, AARD, AASS, ADAT1, AGXT, APIP, arfaptin 1, ASCT2, ASL, AsnRS, ASNSD1, Asparagine synthetase, ASPG, AZ1, biotinidase, C8orf13, CDO, CPS II, CPS1, CPS2, cryptdin 6, CTP, CTP Synthase (CTPS), CTPS, CTPS2, CTU2, D930020E02Rik, DNA pol γ, DPEP1, DPEP2, Ear12, EG232801, eIF4AI, Gamma-glutamyltransferase (GGT), GCAT, GFAT1, GFAT2, GGCT, GGL, GGT, Gl Syn, GLOD4, GLULD1, Glutathione reductase, GlyRS, GNA1, GNPDA2, Golgin 45, GSH-1, KIAA0649, LOC345630, LOC644196, NHP2, PRODH, PRPS1, PRPSL1, QAPRTase, RPA16, SLC35F1, SLC38A11, SLC38A8, TGase1, Trp E, UROC1, Vav2, and ZCCHC4.Activator of:
AlaRS, Glutamine-rich 1, KNP-I, and PEPT2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acivicin, 1 mg | sc-200498B | 1 mg | $102.00 | |||
Acivicin, 5 mg | sc-200498C | 5 mg | $408.00 | |||
Acivicin, 10 mg | sc-200498 | 10 mg | $642.00 | |||
Acivicin, 25 mg | sc-200498D | 25 mg | $1275.00 |