PRDM3 Activators
PRDM3, also known by the name PR domain zinc finger protein 3, is a transcriptional regulator that belongs to the PRDM family of proteins, which are characterized by the presence of a PR domain related to the SET domain methyltransferase family. This protein functions in the nucleus and is involved in a myriad of cellular processes, including the modulation of gene expression, which it achieves through chromatin remodeling activities. The PR domain of PRDM3 suggests its role in the methylation of histone proteins, a post-translational modification that can either repress or activate gene transcription depending on the specific histone and lysine residue that is methylated. As a result of its regulatory potential, PRDM3 is posited to play a pivotal role in cellular differentiation, growth control, and the maintenance of cellular identity. Understanding the regulation of PRDM3 is crucial, as its expression levels can influence the transcriptional landscape of a cell, and consequently, a host of cellular functions.
In exploring the regulation of PRDM3 expression, various non-peptidic chemical compounds have been identified that can potentially act as activators. These compounds exert their effects through diverse mechanisms, each interfacing with the cell's intricate network of signaling and epigenetic modulation. For instance, compounds like 5-Azacytidine and Epigallocatechin gallate are known to interact with the DNA methylation machinery, potentially leading to a more transcriptionally permissive chromatin state and an increase in the expression of genes like PRDM3. Similarly, histone deacetylase inhibitors such as Trichostatin A and Sodium butyrate can result in an open chromatin conformation around the PRDM3 locus, facilitating its transcription. Other molecules such as Retinoic acid and Forskolin may upregulate PRDM3 through receptor-mediated signaling pathways, which can culminate in the activation of transcription factors that specifically target the PRDM3 promoter. Each of these activators operates through a unique pathway, but all converge on the common outcome of enhancing PRDM3 gene expression, thereby shedding light on the complex regulatory network that controls this protein's levels within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could upregulate PRDM3 by causing hypomethylation of its promoter region, thus enhancing transcriptional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may induce PRDM3 expression by halting the deacetylation of histones, thereby opening up the chromatin structure around the PRDM3 gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can stimulate PRDM3 synthesis by binding to retinoic acid receptors that interact with the gene's promoter elements to initiate transcription. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
3,3'-Diindolylmethane might increase PRDM3 levels by activating aryl hydrocarbon receptor signaling, which can lead to the transcriptional activation of certain genes, including PRDM3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate could promote PRDM3 expression through the inhibition of DNA methyltransferases, resulting in decreased methylation of the PRDM3 gene promoter. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane might stimulate the production of PRDM3 by triggering the Nrf2 signaling pathway, which can initiate the transcription of antioxidant response genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may upregulate PRDM3 by deactivating the transcription factor NF-κB, leading to a reduction in the repression of certain genes, including PRDM3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can increase PRDM3 transcription by stimulating sirtuin 1, an enzyme that deacetylates histones and other proteins, affecting gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may stimulate the expression of PRDM3 by inhibiting glycogen synthase kinase-3, which can lead to the activation of Wnt signaling and transcriptional changes in several genes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can induce PRDM3 by elevating intracellular cAMP levels, which in turn activates protein kinase A (PKA) and leads to the phosphorylation of transcription factors that bind to the PRDM3 promoter. | ||||||