PRAMEF5 Inhibitors
PRAMEF5 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of PRAMEF5, a protein belonging to the Preferentially Expressed Antigen in Melanoma Family (PRAME). PRAMEF5, similar to other members of the PRAME family, is believed to play a significant role in regulating gene expression by interacting with transcriptional machinery and modulating cellular processes such as proliferation, differentiation, and survival. Though not extensively characterized, PRAMEF5 is thought to participate in transcriptional repression or activation, controlling the expression of genes involved in maintaining cellular homeostasis, development, and stress responses. By inhibiting PRAMEF5, researchers can disrupt these regulatory mechanisms, offering a tool to investigate the specific functions of PRAMEF5 in transcriptional control and cellular dynamics.
In research, PRAMEF5 inhibitors are valuable for studying the molecular mechanisms underlying gene regulation and the role PRAMEF5 plays in controlling cellular behavior. By blocking PRAMEF5 activity, scientists can explore how inhibition affects the transcription of specific gene targets regulated by this protein, providing insights into its impact on cellular processes such as cell cycle progression, differentiation, and apoptosis. This inhibition allows for the investigation of the downstream effects on cellular signaling pathways, revealing how PRAMEF5 contributes to maintaining cellular identity and modulating responses to environmental cues. Additionally, PRAMEF5 inhibitors provide insights into the interactions between PRAMEF5 and other proteins involved in transcriptional regulation, offering a deeper understanding of the complex networks that control gene expression. Through these studies, the use of PRAMEF5 inhibitors advances our knowledge of transcriptional regulation, PRAME family functions, and their broader implications in cellular homeostasis and adaptability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent can cause hypomethylation of DNA, potentially reactivating tumor suppressor genes that could downregulate PRAMEF5 expression through trans-repressive mechanisms or by alteration of the methylation status of the PRAMEF5 gene promoter directly, leading to reduced transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine's incorporation into DNA may lead to the hypomethylation of the PRAMEF5 gene promoter, thereby reducing the transcriptional activity of the gene by preventing the binding of methyl-CpG-binding domain proteins that normally promote gene silencing. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could induce hyperacetylation of histones associated with the PRAMEF5 gene, resulting in the loosening of chromatin structure and the consequent displacement of transcriptional repressors, thereby decreasing PRAMEF5 mRNA synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase, Trichostatin A can promote the accumulation of acetylated histones, leading to a more open chromatin state that may disrupt transcriptional activators from initiating PRAMEF5 gene expression. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin may inhibit histone deacetylases, causing an increase in acetylated histones, which could lead to a reduction in PRAMEF5 expression by altering the chromatin landscape around the gene and blocking the assembly of the transcriptional machinery. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275's inhibition of histone deacetylases could result in an accumulation of acetylated histones, which can suppress the expression of PRAMEF5 by impeding the access of transcriptional activators to the gene's promoter region. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
By inhibiting histone deacetylase, valproic acid can lead to elevated levels of histone acetylation, potentially decreasing PRAMEF5 expression by disrupting the chromatin structure necessary for its gene transcription. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can chelate copper, an essential cofactor for the NF-κB and potentially reduce PRAMEF5 expression by attenuating NF-κB-mediated transcriptional activation of the gene. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This MEK inhibitor could suppress the ERK pathway, leading to a decrease in the phosphorylation of transcription factors that are essential for PRAMEF5 expression, thereby reducing its mRNA levels. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
By targeting and inhibiting PI3K, LY 294002 can downregulate the AKT signaling pathway, potentially leading to the suppression of transcription factors and resulting in decreased PRAMEF5 gene expression. | ||||||