PP6R3 Activators
PP6R3 Activators are a diverse collection of chemical compounds that indirectly enhance the functional activity of the protein phosphatase PP6R3. Okadaic Acid, Calyculin A, Fostriecin, Cantharidin, Microcystin-LR, Endothall, and Tautomycin all serve as inhibitors of protein phosphatases such as PP1 and PP2A; their action can lead to a compensatory increase in PP6R3 activity as the cell attempts to maintain a balance in phosphatase activities. This indirect mode of activation puts PP6R3 in a position of greater relative influence over dephosphorylation processes within the cell. Similarly, Ionomycin, by raising intracellular calcium levels, might bolster PP6R3 activity indirectly through the activation of calcium-dependent protein phosphatases that work in concert with PP6R3 to regulate cellular dephosphorylation networks.
The activity of PP6R3 is further influenced by Forskolin, which by elevating cAMP levels, indirectly promotes PP6R3's role in counteracting phosphorylation through cAMP-dependent PKA signaling. Zoledronic Acid, through its interference with phosphate-based enzymes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, okadaic acid can indirectly enhance the activity of PP6R3 by shifting the cellular balance of phosphatase activity in favor of PP6. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to okadaic acid, calyculin A inhibits PP1 and PP2A, which could indirectly upregulate PP6R3 activity by competitive inhibition. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
This phosphate ester acts as an inhibitor of PP2A and PP4, potentially leading to enhanced PP6R3 activity through compensatory cellular mechanisms. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
By inhibiting PP1 and PP2A, cantharidin could indirectly increase PP6R3 activity due to reduced competition. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
As an inhibitor of PP2A, endothall could potentially enhance PP6R3 activity by altering the phosphatase activity balance. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
This inhibitor of PP1 and PP2A may indirectly promote PP6R3 activity by reducing the activity of these competing phosphatases. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium, ionomycin could enhance PP6R3 activity by activating calcium-dependent protein phosphatases, thus affecting the dephosphorylation balance. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By increasing cAMP levels and activating PKA, forskolin can indirectly enhance PP6R3 by promoting phosphorylation events that PP6 can counteract, thus highlighting its role. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
As a bisphosphonate, zoledronic acid can interfere with pyrophosphate and phosphate-based enzyme reactions, potentially affecting PP6R3's regulation of dephosphorylation processes. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
An inhibitor of fatty acid synthase that may lead to changes in lipid metabolism, potentially affecting the membrane association and activity of PP6R3. | ||||||