PP2B-Aγ Inhibitors
PP2B-Aγ inhibitors play a crucial role in modulating cellular signaling pathways and calcium homeostasis. Cyclosporin A and FK506 are direct inhibitors of PP2B-Aγ, forming complexes with cyclophilin and FKBP, respectively, leading to the inhibition of PP2B-Aγ activity. These inhibitors affect the enzyme's role in intracellular signaling and calcium regulation, potentially influencing various cellular processes. Delphinidin, Naringin, Dihydromyricetin, and Quercetin indirectly modulate PP2B-Aγ by influencing calcium signaling pathways. This modulation impacts PP2B-Aγ's role in cellular signaling pathways, potentially leading to alterations in intracellular signaling processes dependent on PP2B-Aγ.
Calcineurin Autoinhibitory Peptide is a synthetic peptide that directly inhibits PP2B-Aγ by mimicking the autoinhibitory domain of calcineurin, affecting PP2B-Aγ's catalytic activity and potentially leading to alterations in cellular processes regulated by PP2B-Aγ. Monensin influences PP2B-Aγ indirectly by affecting ion homeostasis, while Forskolin modulates adenylate cyclase activity and cAMP levels, impacting PP2B-Aγ's role in cellular signaling pathways. FTY720 directly inhibits PP2B-Aγ by phosphorylating the autoinhibitory domain, affecting catalytic activity and cellular processes. Norcantharidin is a synthetic derivative that directly inhibits PP2B-Aγ by disrupting its catalytic activity. Lastly, BAPTA, a calcium chelator, indirectly modulates PP2B-Aγ by disrupting calcium signaling pathways, potentially leading to alterations in intracellular signaling pathways regulated by PP2B-Aγ.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is a cyclic peptide that directly inhibits PP2B-Aγ by forming a complex with cyclophilin, leading to the inhibition of PP2B-Aγ activity. This direct inhibition impacts PP2B-Aγ's role in intracellular signaling and calcium homeostasis, potentially affecting cellular processes dependent on PP2B-Aγ. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506, also known as Tacrolimus, directly inhibits PP2B-Aγ by forming a complex with FK506-binding protein (FKBP), leading to the inhibition of PP2B-Aγ activity. This direct inhibition affects PP2B-Aγ's involvement in cellular signaling pathways and calcium regulation, potentially influencing various cellular processes. | ||||||
Naringin | 10236-47-2 | sc-203443 sc-203443A | 25 g 50 g | $45.00 $101.00 | 7 | |
Naringin, a flavonoid glycoside, indirectly modulates PP2B-Aγ by affecting calcium homeostasis. This indirect modulation can influence PP2B-Aγ's role in cellular signaling pathways, potentially leading to alterations in intracellular signaling processes dependent on PP2B-Aγ. | ||||||
Ampeloptin | 27200-12-0 | sc-480419 | 10 mg | $300.00 | ||
Ampeloptin is a natural flavonoid that indirectly modulates PP2B-Aγ by influencing calcium signaling pathways. This indirect modulation can impact PP2B-Aγ's activity in cellular processes dependent on calcium regulation, potentially leading to alterations in intracellular signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, indirectly modulates PP2B-Aγ by affecting calcium homeostasis. This indirect modulation can influence PP2B-Aγ's role in cellular signaling pathways, potentially leading to alterations in intracellular signaling processes dependent on PP2B-Aγ. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a polyether antibiotic that indirectly modulates PP2B-Aγ by influencing ion homeostasis. This indirect modulation can impact PP2B-Aγ's activity in cellular processes dependent on ion regulation, potentially leading to alterations in intracellular signaling pathways regulated by PP2B-Aγ. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene derivative that indirectly modulates PP2B-Aγ by influencing adenylate cyclase activity and cAMP levels. This indirect modulation can impact PP2B-Aγ's role in cellular signaling pathways, potentially leading to alterations in intracellular signaling processes dependent on PP2B-Aγ. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720, also known as Fingolimod, directly inhibits PP2B-Aγ by phosphorylating the autoinhibitory domain, leading to the inhibition of PP2B-Aγ activity. This direct inhibition affects PP2B-Aγ's catalytic activity, potentially leading to alterations in cellular processes regulated by PP2B-Aγ. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $113.00 | 2 | |
Norcantharidin is a synthetic derivative of cantharidin that directly inhibits PP2B-Aγ by disrupting its catalytic activity. This direct inhibition affects PP2B-Aγ's role in intracellular signaling pathways, potentially leading to alterations in cellular processes dependent on PP2B-Aγ. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $68.00 $267.00 | 10 | |
BAPTA is a synthetic calcium chelator that indirectly modulates PP2B-Aγ by disrupting calcium signaling pathways. This indirect modulation can impact PP2B-Aγ's activity in cellular processes dependent on calcium regulation, potentially leading to alterations in intracellular signaling pathways regulated by PP2B-Aγ. | ||||||