Molecular structure of Norcantharidin, CAS Number: 29745-04-8
Norcantharidin (CAS 29745-04-8)
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Alternate Names:
exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride
Application:
Norcantharidin is a potential antitumor agent
CAS Number:
29745-04-8
Purity:
≥98%
Molecular Weight:
168.15
Molecular Formula:
C8H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride is a compound that functions as a reactive intermediate in organic synthesis. It acts as a versatile building block for the construction of complex molecular structures due to its ability to undergo various chemical transformations. Exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydrideis utilized for the synthesis of novel organic compounds and materials. Its mode of action involves participating in Diels-Alder reactions, ring-opening reactions, and other transformations to introduce functional groups and create diverse chemical structures.
Norcantharidin (CAS 29745-04-8) References
- Norcantharidin Inhibits SK-N-SH Neuroblastoma Cell Growth by Induction of Autophagy and Apoptosis. | Han, Z., et al. 2017. Technol Cancer Res Treat. 16: 33-44. PMID: 26755751
- Effect of norcantharidin on the proliferation, apoptosis, and cell cycle of human mesangial cells. | Ye, K., et al. 2017. Ren Fail. 39: 458-464. PMID: 28393592
- Norcantharidin-blocked ANXA2P2 inhibits fibroblast proliferation by increasing UBAP2L mRNA stability through LIN28B. | Huang, R., et al. 2021. Life Sci. 279: 119645. PMID: 34043991
- Norcantharidin counteracts acquired everolimus resistance in renal cell carcinoma by dual inhibition of mammalian target of rapamycin complex 1 and complex 2 pathways in Vitro. | Chen, X., et al. 2022. Anticancer Drugs. 33: e94-e102. PMID: 34261913
- Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells. | Du, LJ., et al. 2022. Acta Pharmacol Sin. 43: 1521-1533. PMID: 34552214
- Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity. | Liu, Z., et al. 2022. Expert Opin Drug Deliv. 19: 451-464. PMID: 35385376
- Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture. | Xu, L., et al. 2022. Int J Mol Sci. 23: PMID: 35409302
- Norcantharidin promotes cancer radiosensitization through Cullin1 neddylation-mediated CDC6 protein degradation. | Deng, T., et al. 2022. Mol Carcinog. 61: 812-824. PMID: 35652616
- Norcantharidin down-regulates iron contents in the liver and spleen of lipopolysaccharide-treated mice. | Zheng, J., et al. 2022. Redox Rep. 27: 119-127. PMID: 35735222
- Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway. | Wang, L., et al. 2022. Front Pharmacol. 13: 906043. PMID: 36034784
- Regio-selective synthesis and activity research on 7-icaritin norcantharidin conjugates. | Dong, W., et al. 2022. Nat Prod Res. 1-9. PMID: 36095033
- Norcantharidin induces ferroptosis via the suppression of NRF2/HO-1 signaling in ovarian cancer cells. | Zhu, X., et al. 2022. Oncol Lett. 24: 359. PMID: 36168316
- Norcantharidin attenuates epidermal growth factor-induced proliferation, EMT and motility in ARPE-19 cells by modulating the AKT/snail/E-cadherin axis. | Chien, HW., et al. 2022. Life Sci. 311: 121157. PMID: 36356893
- Norcantharidin ameliorates estrogen deficient-mediated bone loss by attenuating the activation of extracellular signal-regulated kinase/ROS/NLRP3 inflammasome signaling. | Yang, G., et al. 2022. Front Pharmacol. 13: 1019478. PMID: 36408264
- Downregulation of hepcidin by norcantharidin in macrophage. | Zheng, J., et al. 2023. Nat Prod Res. 1-6. PMID: 36855296
Inhibitor of:
4921523A10Rik, ALP, C7orf47, CCDC25, Cdc14b Phosphatase, CPPED1, E-cadherin, Gm70, I1PP2A, PHACTR3, phosphatasefamily surface anchored protein, PME-1, PP1α, PP2A-Aα, PP2A-Bα, PP2A-B55-α, PP2A-B56-δ, PP2A-B72/B130, PP2A-Cβ, PP2B-Aγ, PP2C, PP2Cε, PP4R1, PPEF-2, PPP2R3A, and PPP2R4.Activator of:
ANP32C, Cdc14b Phosphatase, Dkk-4, DUSP28, FAM46C, nephrocystin, Neurabin-I, Nrdp1, PP2A-δ, PP2A-γ, PP2A-Bα, Ppp2r3d, Smad7, and SSH3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Norcantharidin, 5 g | sc-280719 | 5 g | $111.00 |