PP2B-Aγ Antibody (4D1): sc-293361

PP2B-Aγ Antibody (4D1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PP2B-A gamma protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PP2B-A gamma antibody (4D1) is available as a non-conjugated format. PP2B-A gamma protein, also called Calcineurin A gamma (CnAγ), plays a crucial role in cellular signaling pathways, particularly in the regulation of calcium-dependent processes. PP2B-A gamma protein is a part of the protein phosphatase 2B (PP2B) family, which is essential for dephosphorylating serine and threonine residues on target proteins, thereby influencing various cellular functions such as cell division, apoptosis, and homeostasis. PP2B-A gamma subunit, along with regulatory partners, forms a trimeric complex that is vital for enzyme activity and specificity. Understanding PP2B-A gamma function is important because dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders. Using PP2B-A gamma monoclonal antibody (4D1) in research can provide insights into intricate signaling mechanisms that govern cellular behavior and contribute to disease pathology.

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PP2B-Aγ Antibody (4D1) References:

1. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).  |  Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
2. Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population.  |  Kyogoku, C., et al. 2011. Psychiatry Res. 185: 16-9. PMID: 20537399
3. Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.  |  Osier, ND., et al. 2017. J Neurotrauma. 34: 86-96. PMID: 27225880
4. Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation.  |  Chen, H., et al. 2021. J Cell Physiol. 236: 5698-5714. PMID: 33393109
5. Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer.  |  Anastasiadou, E., et al. 2021. Genes (Basel). 12: PMID: 34573382
6. Shikonin reactivates TSGs GADD45B and PPP3CC to block NSCLC cell proliferation and migration through JNK/P38/MAPK signaling pathways.  |  Zhao, Y., et al. 2024. BMC Complement Med Ther. 24: 10. PMID: 38167059
7. Serine/threonine protein phosphatases.  |  Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
8. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.  |  Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
9. A regulatory subunit of smooth muscle myosin bound phosphatase.  |  Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
10. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.  |  Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
11. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth.  |  Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923
12. Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1.  |  Lohse, DL., et al. 1995. Structure. 3: 987-90. PMID: 8590008

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PP2B-Aγ Antibody (4D1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PP2B-Aγ Antibody (4D1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PP2B-Aγ Antibody (4D1) Specifications

Alternate Product Name: PP2B-Aγ

Product Clone Name: 4D1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-81

Epitope Target: PP2B-Aγ

Epitope Species: human

Product Reactivity/Detection: PP2B-Aγ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PP2B-Aγ Antibody (4D1): N/A