Naringin hydrate is a citrus bioflavonoid found to inhibit cytochrome P450 monooxygenase activity in mouse liver. Naringin hydrate prevents toxin-induced cytoskeletal disruption and apoptotic liver cell death. In addition, it was found to have hypocholesterolemic effect by inhibiting HMG-CoA reductase as well as ACAT activities. Naringin hydrate is an inhibitor of CYP1A2 and CYP3A4. Naringin is an inhibitor of OATP.
1. Ueng, Y.F., et al. 1999. Life Sci. 65: 2591-2602. PMID: 10619367 2. Shin, Y.W., et al. 1999. Int. J. Vit. Nutr. Res. 69: 341-347. PMID: 10526779 3. Blankson H, et al. 2000. Cell Death Diff. 7: 739-746. PMID: 10918448
Soluble in water (1 mg/ml), alcohol, acetone, and warm acetic acid.
Store at room temperature
166° C (lit.)(dec.)
n20D 1.71 (Predicted)
α20/D -90°, c = 1 in ethanol; α20/D -83.5°±8.5°, c = 2 in ethanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Adeniyi AO; et alAdeniyi AO; et al. (PubMed ID: 26421421) determine that Naringin decreases cardiac hypertrophy by inhibiting oxidative stress by inactivation of JNK-1. -SCBT Publication Review
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