Naringin CAS: 10236-47-2
MF: C27H32O14
MW: 580.53
A citrus bioflavonoid reported to inhibit cytochrom P450 monooxygenase activity.

Naringin (CAS 10236-47-2)

Naringin | CAS 10236-47-2 is rated 5.0 out of 5 by 1.
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Alternate Names: 4',5,7-trihydroxyflavanone 7-rhamnoglucoside
Application: Naringin is a citrus bioflavonoid reported to inhibit cytochrom P450 monooxygenase activity
CAS Number: 10236-47-2
Purity: ≥98%
Molecular Weight: 580.53
Molecular Formula: C27H32O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Naringin hydrate is a citrus bioflavonoid found to inhibit cytochrome P450 monooxygenase activity in mouse liver. Naringin hydrate prevents toxin-induced cytoskeletal disruption and apoptotic liver cell death. In addition, it was found to have hypocholesterolemic effect by inhibiting HMG-CoA reductase as well as ACAT activities. Naringin hydrate is an inhibitor of CYP1A2 and CYP3A4. Naringin is an inhibitor of OATP.


References

1. Ueng, Y.F., et al. 1999. Life Sci. 65: 2591-2602. PMID: 10619367
2. Shin, Y.W., et al. 1999. Int. J. Vit. Nutr. Res. 69: 341-347. PMID: 10526779
3. Blankson H, et al. 2000. Cell Death Diff. 7: 739-746. PMID: 10918448

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml), alcohol, acetone, and warm acetic acid.
Storage :
Store at room temperature
Melting Point :
166° C (lit.)(dec.)
Refractive Index :
n20D 1.71 (Predicted)
Optical Activity :
α20/D -90°, c = 1 in ethanol; α20/D -83.5°±8.5°, c = 2 in ethanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QN6340000
PubChem CID :
4441
Merck Index :
14: 6424
MDL Number :
MFCD00149445
EC Number :
233-566-4
Beilstein Registry :
102012
SMILES :
CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Naringin (CAS 10236-47-2)  Product Citations

See how others have used Naringin (CAS 10236-47-2). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26202868  Sadowska-Bartosz, I. et al. 2015. Redox Biol. 6: 93-9.

PMID: # 29389596  Food Res. Int. 103: 110-120.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Adeniyi AO; et al Adeniyi AO; et al. (PubMed ID: 26421421) determine that Naringin decreases cardiac hypertrophy by inhibiting oxidative stress by inactivation of JNK-1. -SCBT Publication Review
Date published: 2015-03-30
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