PP2A-Bα Activators
PP2A-Bα Activators encompass a diverse array of chemical compounds that modulate cellular phosphatase activity, specifically altering the functional dynamics of PP2A-Bα. Fostriecin, for instance, fine-tunes the balance of phosphatase activity by selectively inhibiting PP2A over PP1, thereby enhancing the functional phosphatase activity of PP2A-Bα. Similarly, Okadaic Acid, at low concentrations, preferentially inhibits PP1, thus indirectly augmenting PP2A-Bα activity by reducing its competitive inhibition. Cantharidin and Norcantharidin, by inhibiting other phosphatases more strongly, shift the equilibrium towards an increase in PP2A-Bα activity. Compounds like (S)-Perillyl alcohol and Endothall contribute to the specificity of PP2A-Bα activation through modulating signaling pathways where PP2A-Bα has a regulatory role, such as the Ras signaling pathway in the case of (S)-Perillyl alcohol.
Additional compounds such as Calyculin A and Tautomycin, though known as general PP2A inhibitors, at nuanced dosages, can indirectly bolster PP2A-Bα activity through selective inhibition of PP1 or differential effects on PP2A holoenzymes. Microcystin-LR, through its allosteric interactions, may fine-tune the substrate specificity of PP2A-Bα, and Phenylarsine Oxide by impacting the redox state of PP2A-Bα, can lead to conformational changes enhancing its activity. LB-100, while inhibiting PP2A, can under certain conditions preferentially activate PP2A-Bα, and similarly, Rubratoxin B, by inhibiting other PP2A holoenzymes, can indirectly result in an upregulation of PP2A-Bα activity. Collectively, these chemicals define a landscape where PP2A-Bα activation is modulated through a delicate balance of phosphatase activities and pathway interactions, ensuring precise control over PP2A-Bα's role in cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
Fostriecin selectively inhibits PP2A over PP1 due to the unique structural conformation when bound to PP2A-Bα. This chemical interaction enhances PP2A-Bα phosphatase activity, leading to dephosphorylation of its specific substrates. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of PP1 and PP2A, but at low concentrations, it has been shown to preferentially inhibit PP1, which can indirectly enhance the activity of PP2A-Bα by reducing competition. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin inhibits PP2A along with other phosphatases, and at specific concentration levels, it can preferentially affect other phosphatases, thereby indirectly enhancing PP2A-Bα activity by altering phosphatase equilibrium. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Endothall is an organochlorine compound that inhibits PP2A, but through competitive inhibition, it may selectively modulate the activity of PP2A-Bα over other PP2A isoforms, leading to a relative increase in its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, like okadaic acid, is a potent inhibitor of PP1 and PP2A, but at lower concentrations, it can preferentially inhibit PP1, potentially resulting in an indirect increase in PP2A-Bα activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tautomycin targets PP1 and PP2A; however, its binding affinity varies between the two, which could be exploited to enhance PP2A-Bα activity indirectly by altering the balance of phosphatase activities. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $111.00 | 2 | |
Norcantharidin is a demethylated analog of cantharidin with similar inhibitory effects on PP2A. It could indirectly increase PP2A-Bα activity by influencing the overall phosphatase activity balance in cells. | ||||||
LB-100 | 1632032-53-1 | sc-507368 | 10 mg | $330.00 | ||
LB-100 is a small molecule inhibitor of PP2A, which can preferentially affect certain PP2A holoenzymes over others, potentially leading to an enhancement of PP2A-Bα activity under specific conditions. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine Oxide is known to bind to vicinal dithiols and could indirectly modulate PP2A-Bα activity by affecting the redox state and, thus, the conformation of PP2A-Bα, leading to changes in its activity. | ||||||