PNRC2 Inhibitors
Chemical inhibitors of PNRC2 include a range of compounds that target various pathways and cellular processes in which PNRC2 is involved. Trichostatin A, as a histone deacetylase inhibitor, impedes the chromatin remodeling required for PNRC2 to access and regulate certain genes, thereby inhibiting its role in gene expression. Proteasome inhibitors such as MG132 and Lactacystin disrupt the ubiquitin-proteasome system, a pathway crucial for protein degradation. PNRC2's function is tied to this system, and the accumulation of proteins due to proteasome inhibition can impede PNRC2's regulatory activities. Similarly, Bortezomib's action on the proteasome interferes with the degradation of proteins that PNRC2 targets, thwarting its function.
In the realm of kinase inhibitors, LY294002 and Wortmannin specifically target the PI3K/AKT signaling pathway, leading to a halt in downstream signaling activities in which PNRC2 is involved, thus inhibiting its function. PD98059 and U0126, which inhibit MEK1/2, prevent the activation of ERK, a key event in the MAPK/ERK pathway that is associated with PNRC2's signaling functions. In a parallel manner, SB203580's inhibition of p38 MAPK and SP600125's inhibition of JNK, both parts of the MAPK pathway, can lead to a reduction in PNRC2's role in mediating cellular responses to various stimuli. Rapamycin's inhibition of mTOR disrupts protein synthesis and degradation pathways, affecting PNRC2's associated roles. Lastly, IKK Inhibitor VII's specific targeting of IKK impedes the NF-κB signaling pathway, which is another signaling cascade PNRC2 has been implicated in, thus leading to an inhibition of PNRC2's ability to regulate gene expression mediated by NF-κB.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. PNRC2 is known to function as a coactivator for nuclear receptors and likely interacts with acetylated histones. By inhibiting histone deacetylases, Trichostatin A could prevent the remodeling of chromatin that is necessary for PNRC2 to access certain genes it regulates, thus inhibiting PNRC2's role in gene expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. PNRC2 is involved in the regulation of protein degradation via the ubiquitin-proteasome system. Inhibition of the proteasome by MG132 can lead to an accumulation of proteins that are targeted for degradation, which could include regulatory proteins that PNRC2 interacts with, thereby functionally inhibiting PNRC2's role in this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PNRC2 has been implicated in signal transduction pathways that involve PI3K. Inhibition of PI3K by LY294002 would disrupt downstream signaling that PNRC2 may be involved in, thereby inhibiting its function in these pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. PNRC2 operates within various signaling pathways including those involving MAPK/ERK. By inhibiting MEK, PD98059 can reduce the activation of ERK and thus inhibit PNRC2's role in mediating cellular responses that depend on this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. Similar to LY294002, wortmannin's inhibition of PI3K would halt the PI3K/AKT signaling cascade, which PNRC2 may be involved in, leading to an inhibition of PNRC2's functional activity in these pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. PNRC2 has been associated with MAPK signaling pathways. Inhibition of p38 MAPK by SB203580 can affect the cellular processes governed by this kinase, which could include processes regulated by PNRC2, thus inhibiting its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Given that PNRC2 is implicated in protein synthesis and degradation pathways, rapamycin's inhibition of mTOR could disrupt these pathways, leading to a functional inhibition of PNRC2. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, enzymes upstream of ERK in the MAPK pathway. Inhibiting MEK1/2 with U0126 would prevent the activation of ERK, which in turn could inhibit PNRC2's associated signaling functions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, another MAPK pathway component. PNRC2's function is associated with MAPK signaling, and inhibition of JNK by SP600125 could inhibit PNRC2's role in cellular response to various stimuli. | ||||||
[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone | 873225-46-8 | sc-503387 | 10 mg | $430.00 | ||
IKK Inhibitor VII is a specific inhibitor of IKK, which is part of the NF-κB signaling pathway. PNRC2 has been implicated in NF-κB signaling, and inhibition of IKK could impair PNRC2's functional activity in regulating gene expression mediated by NF-κB. | ||||||