PLSCR3 Activators
PLSCR3 activators encompass a variety of chemical entities that indirectly augment the scramblase activity of PLSCR3 through distinct cellular signaling pathways and biophysical membrane alterations. Compounds like Sphingosine-1-phosphate and Miltefosine operate by engaging with lipid signaling cascades or integrating into cellular membranes, respectively, thereby altering the membrane dynamics to favor PLSCR3's function in phospholipid scrambling. Similarly, the calcium ionophore A23187 elevates intracellular calcium levels, directly enhancing PLSCR3 scramblase activity, which is calcium-dependent. Phorbol 12-myristate 13-acetate (PMA), a known PKC activator, promotes the phosphorylation and subsequent activation of PLSCR3, while Edelfosine and C2-ceramide alter the lipid bilayer's composition, thus potentiating PLSCR3's operational environment. Fatty acids such as Oleic Acid and Arachidonic Acid, by incorporating into cellular membranes, improve membrane fluidity, creating conditions that are more conducive for PLSCR3's lipid externalization functions.
In addition to these, LysoPC and Glucosylceramide, both of which can be integrated into the lipid bilayer, modify membrane curvature and tension, parameters that are crucial for PLSCR3-mediated lipid scrambling. Curcumin, with its propensity to interact with and modulate membrane properties, can facilitate a more active scramblase function of PLSCR3 by altering the physical state of the membrane. Lastly, Resveratrol, through its polyphenolic structure, exerts an influence on the membrane structure and fluidity, which could lead to an enhanced activity of PLSCR3 scramblase. Collectively, these activators operate through various mechanisms that either directly promote the scramblase activity of PLSCR3 or modify the cellular membrane environment to indirectly support PLSCR3's functional role in phospholipid redistribution.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) engages S1P receptors, which initiates a signaling cascade that activates downstream kinases such as PI3K. PI3K activation can lead to the recruitment and activation of PLSCR3 by promoting its translocation to plasma membranes, where PLSCR3 functions in phospholipid scrambling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which in turn can phosphorylate PLSCR3. Phosphorylation of PLSCR3 by PKC is known to enhance its functional activity related to phospholipid scrambling in the plasma membrane. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium concentration, which is a cofactor for PLSCR3 activation. Elevated calcium levels can enhance the scramblase activity of PLSCR3, promoting its role in the externalization of phosphatidylserine. | ||||||
Edelfosine | 70641-51-9 | sc-507459 | 5 mg | $216.00 | ||
Edelfosine is a synthetic alkyl-lysophospholipid that can insert into lipid bilayers and alter membrane structure. Its action can potentiate the scramblase activity of PLSCR3 by modifying the lipid environment in which PLSCR3 operates, thereby facilitating its activity in the membrane. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid, a monounsaturated fatty acid, integrates into cellular membranes, potentially altering their biophysical properties. This alteration can enhance the activity of membrane-associated proteins like PLSCR3 by changing the membrane fluidity, making it more conducive for PLSCR3-mediated lipid scrambling. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $81.00 | 8 | |
Miltefosine is an alkylphosphocholine drug with antineoplastic properties. It integrates into cell membranes and can mimic lysophospholipids, leading to the activation of PLSCR3 by changing the membrane dynamics and promoting its scramblase activity. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
C2-ceramide is a short-chain ceramide that can induce apoptosis and act as a second messenger within cells. By influencing membrane properties and signaling pathways, C2-ceramide can enhance PLSCR3 activity, primarily due to the role of ceramides in inducing cell membrane alterations which may facilitate PLSCR3 scramblase function. | ||||||
L-α-Lysophosphatidylcholine (from egg yolk) | 9008-30-4 | sc-473611 sc-473611A sc-473611B sc-473611C | 25 mg 100 mg 500 mg 1 g | $87.00 $235.00 $607.00 $1102.00 | 1 | |
LysoPC incorporates into cellular membranes and can act as a lysophospholipid, which may modulate the activity of scramblases such as PLSCR3 by altering membrane curvature and tension, potentially enhancing PLSCR3's lipid scrambling capabilities. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid is a polyunsaturated fatty acid that is a key inflammatory mediator. It incorporates into lipid membranes and can enhance PLSCR3 activity by increasing the membrane fluidity and potentially creating a more favorable environment for PLSCR3-mediated lipid scrambling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a biologically active polyphenolic compound that has been shown to interact with cell membranes and modulate their properties. This interaction can lead to an enhanced activity of membrane proteins like PLSCR3 by influencing the membrane's physical state, thus potentially promoting PLSCR3 scramblase activity. | ||||||