Date published: 2026-3-9

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Pim-2 Inhibitors

Pim-2 inhibitors belong to a class of small molecules designed to target and inhibit the activity of the protein kinase known as Pim-2 (Proviral Integration site for Moloney murine leukemia virus 2). Pim-2 is a serine/threonine kinase that plays a crucial role in regulating various cellular processes, primarily through its ability to phosphorylate target proteins. This kinase is a member of the Pim kinase family, which includes Pim-1 and Pim-3, and is known for its involvement in the regulation of cell growth, survival, and proliferation. Pim-2 inhibitors are specifically designed to block the enzymatic activity of Pim-2, thereby modulating the signaling pathways it controls. The development of Pim-2 inhibitors is driven by their ability to influence intracellular signaling cascades that are frequently dysregulated in various diseases, including cancer. By inhibiting Pim-2, these compounds aim to disrupt the phosphorylation of downstream substrates, which can lead to alterations in cellular processes such as cell cycle progression, apoptosis, and gene expression. The rational design of Pim-2 inhibitors typically involves the synthesis and optimization of small molecules that can selectively bind to the active site of the kinase, disrupting its catalytic activity.

Items 1 to 10 of 13 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SMI-4a

327033-36-3sc-364140
5 mg
$95.00
2
(0)

SMI-4a, with CAS number 327033-36-3, is a known chemical inhibitor of Pim-2 kinase. It functions by selectively binding to and inhibiting the activity of Pim-2, thereby modulating the cellular processes in which Pim-2 is involved. The exact mechanism and specificity of SMI-4a's inhibitory action on Pim-2 are subjects of biochemical research.

TCS PIM-1 4a

438190-29-5sc-296450
sc-296450A
10 mg
50 mg
$64.00
$346.00
(0)

TCS PIM-1 4a, CAS 438190-29-5, is a chemical compound recognized for its inhibitory action against Pim kinases, including Pim-2. It operates by binding to Pim-2 kinase, interfering with its activity and influencing related cellular processes. The precise inhibition mechanism and selectivity are areas of active scientific exploration.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin, a flavonoid found in various plants, can downregulate Pim-2 expression. It interferes with signaling pathways, potentially leading to reduced cell proliferation and enhanced apoptosis in cancer cells.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol, a polyphenolic compound, has been shown to suppress Pim-2 expression. This compound interacts with various signaling molecules, possibly disrupting cell survival and proliferation.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

DL-Sulforaphane, found in cruciferous vegetables, has potential to downregulate Pim-2. It influences epigenetic modifications and signaling pathways.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

This compound from green tea has shown potential to inhibit Pim-2 expression. It interacts with various signaling pathways, possibly resulting in anti-proliferative.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein, a soy-derived isoflavone, can suppress Pim-2 expression. It modulates estrogen receptors and related signaling pathways, potentially affecting cell proliferation.

Fisetin

528-48-3sc-276440
sc-276440A
sc-276440B
sc-276440C
sc-276440D
50 mg
100 mg
500 mg
1 g
100 g
$52.00
$79.00
$104.00
$156.00
$2913.00
7
(1)

Fisetin, a flavonol found in fruits and vegetables, can downregulate Pim-2 expression.

Apigenin

520-36-5sc-3529
sc-3529A
sc-3529B
sc-3529C
sc-3529D
sc-3529E
sc-3529F
5 mg
100 mg
1 g
5 g
25 g
100 g
1 kg
$33.00
$214.00
$734.00
$1151.00
$2348.00
$3127.00
$5208.00
22
(1)

Apigenin, a flavone found in many plants, has potential to inhibit Pim-2 expression. It interacts with multiple signaling pathways.

Kaempferol

520-18-3sc-202679
sc-202679A
sc-202679B
25 mg
100 mg
1 g
$99.00
$216.00
$510.00
11
(1)

Kaempferol, a flavonol present in various plants, can suppress Pim-2 expression. It modulates numerous signaling pathways.