SMI-4a (CAS 327033-36-3)
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SMI-4a is a selective inhibitor of the protein kinases, Pim-1 and Pim-2. Induces apoptosis by way of the mitochondrial pathway. Induces G1 phase cell cycle arrest. Inhibits rapamycin C1 (mTORC1) pathway. Inhibits phosphorylation of PRAS40 and mTOR activity. Downregulates c-myc. Regarding the chemistry of SMI-4a, it is a proprietary polyisobutylene (PIB) copolymer developed by Total Corbion PLA. This copolymer offers enhanced adhesion and flexibility in applications like adhesives, sealants, coatings, and elastomers. Composed of polyisobutylene and a cross-linking agent, such as a diisocyanate or polyamine, the copolymer forms a three-dimensional network structure, resulting in improved adhesion and flexibility. It also incorporates additives like plasticizers, antioxidants, and UV stabilizers for further performance enhancements.
SMI-4a (CAS 327033-36-3) References
- A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. | Lin, YW., et al. 2010. Blood. 115: 824-33. PMID: 19965690
- Combination of Pim kinase inhibitors and Bcl-2 antagonists in chronic lymphocytic leukemia cells. | Cervantes-Gomez, F., et al. 2016. Leuk Lymphoma. 57: 436-444. PMID: 26088877
- Clinical and biological significance of PIM1 kinase in osteosarcoma. | Liao, Y., et al. 2016. J Orthop Res. 34: 1185-94. PMID: 26687194
- PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3β. | Fan, RF., et al. 2017. Mol Med Rep. 16: 4603-4612. PMID: 28849186
- Unique anti-myeloma activity by thiazolidine-2,4-dione compounds with Pim inhibiting activity. | Fujii, S., et al. 2018. Br J Haematol. 180: 246-258. PMID: 29327347
- Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death. | Lv, DL., et al. 2018. Chin Med. 13: 11. PMID: 29483938
- PIM inhibitor SMI-4a induces cell apoptosis in B-cell acute lymphocytic leukemia cells via the HO-1-mediated JAK2/STAT3 pathway. | Kuang, X., et al. 2019. Life Sci. 219: 248-256. PMID: 30658101
- Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway. | Jiang, W., et al. 2019. Onco Targets Ther. 12: 3043-3050. PMID: 31114247
- PIM1 inhibitor SMI-4a attenuated lipopolysaccharide-induced acute lung injury through suppressing macrophage inflammatory responses via modulating p65 phosphorylation. | Wang, J., et al. 2019. Int Immunopharmacol. 73: 568-574. PMID: 31203114
- Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer. | Han, X., et al. 2019. Oncogene. 38: 6537-6549. PMID: 31358902
- Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells. | Zhang, X., et al. 2020. Mol Immunol. 125: 15-22. PMID: 32619930
- Protein kinase PIM2: A simple PIM family kinase with complex functions in cancer metabolism and therapeutics. | Wang, Y., et al. 2021. J Cancer. 12: 2570-2581. PMID: 33854618
- PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis. | Wang, M., et al. 2023. Reprod Sci.. PMID: 37059967
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMI-4a, 5 mg | sc-364140 | 5 mg | $95.00 |