PIG-T Inhibitors
PIG-T inhibitors are a distinct class of chemical compounds designed to target and inhibit the enzyme Phosphatidylinositol Glycan class T (PIG-T). This enzyme plays a critical role in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, which are essential glycolipid molecules that tether proteins to the cell membrane. Specifically, PIG-T is responsible for transferring mannose to the precursor of GPI, an important step in the assembly of the GPI anchor structure. Given the significance of GPI anchors in various cellular functions, including signaling, cell adhesion, and protein localization, the inhibition of PIG-T has become a focal point for understanding the complexities of GPI biosynthesis and its subsequent effects on cellular behavior.
The study of PIG-T inhibitors provides insights into the biochemical pathways involved in GPI anchor formation. By disrupting the activity of PIG-T, these inhibitors allow researchers to investigate how changes in GPI biosynthesis impact the production and function of GPI-anchored proteins. GPI-anchored proteins are involved in critical cellular processes, such as immune responses, neuronal signaling, and cellular differentiation. Thus, PIG-T inhibitors serve as valuable tools for dissecting the intricate relationships between GPI biosynthesis and various physiological processes. Furthermore, the exploration of this chemical class can enhance the understanding of how aberrations in GPI anchor metabolism can lead to altered cellular functions, paving the way for more detailed studies into the fundamental aspects of cell biology and molecular interactions. Overall, PIG-T inhibitors are significant for elucidating the mechanistic roles of GPI anchors in health and disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A could downregulate PIG-T expression by increasing acetylation of histones, leading to a more open chromatin structure and altering transcription factor accessibility to the PIG-T gene promoter. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine may reduce PIG-T mRNA levels by causing DNA hypomethylation at the gene promoter, which would interfere with the binding of methyl-CpG-binding proteins and associated repressors. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG 108 could decrease the expression of PIG-T by preventing the methylation of cytosine residues within the gene's promoter, thereby disrupting the normal epigenetic silencing mechanisms. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid might decrease PIG-T expression by binding to retinoid receptors, which then bind retinoic acid response elements in gene promoters, potentially including that of PIG-T, and repress transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin could inhibit PIG-T synthesis by directly inhibiting mTORC1 complex activity, leading to a decrease in the cap-dependent translation initiation of many mRNAs. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY2 94002 may downregulate PIG-T expression by inhibiting PI3K, which would reduce the activity of downstream AKT signaling and thereby decrease transcriptional activity of genes under AKT control. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin could lead to a decrease in PIG-T expression by irreversibly inhibiting PI3K, which leads to reduced AKT phosphorylation and subsequent transcriptional changes in AKT-regulated genes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 may inhibit PIG-T expression by inhibiting JNK activity, which is known to phosphorylate transcription factors that can bind the PIG-T gene promoter region and repress transcription. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 could reduce the expression of PIG-T by inhibiting p38 MAPK, which may play a role in the stress-induced transcriptional activation of the PIG-T gene. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 may prevent PIG-T expression by inhibiting MEK1/2, which are upstream of ERK1/2 in the MAPK pathway; suppressed ERK activation can lead to reduced transcriptional activation of genes. | ||||||