phostensin Activators
Phostensin activators encompass a specialized class of chemical compounds that specifically enhance the functional activity of phostensin, a protein known for its role in the regulation of actin filament dynamics. These activators typically function by influencing the signaling pathways that phostensin is involved in, thereby increasing its ability to bind to actin depolymerizing factor (ADF)/cofilin-actin rods within cells. This interaction is crucial for the modulation of actin filament assembly and disassembly, a process vital for various cellular functions including cell motility, division, and maintenance of cell shape. For instance, certain small molecule ligands can bind to phostensin, altering its conformation in such a way that its affinity for these actin rods is increased, thereby enhancing its activity. Another subset of phostensin activators may work indirectly by influencing the phosphorylation state of phostensin; for example, kinase inhibitors that target upstream regulatory kinases can result in the enhanced activity of phostensin by preventing its inactivation through phosphorylation.
Moreover, some activators can elevate the levels of secondary messengers within the cell, providing an indirect route to phostensin activation. These secondary messengers can then initiate a cascade of intracellular events leading to the activation of proteins that interact with phostensin, thereby promoting its function in actin filament stabilization. Phostensin activators might also affect the cellular localization of phostensin, ensuring it is in the proximity of actin filaments and thus more effectively exerting its role in cytoskeletal dynamics. The specificity of these activators is attributed to the precise molecular interactions that they engage in, which are designed to influence phostensin's activity without altering the expression levels or requiring direct binding to the actin filaments themselves. Through these multifaceted mechanisms, phostensin activators are integral to the fine-tuning of cellular architecture and function by modulating the actin cytoskeleton dynamics in a controlled and precise manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of PKA. Phostensin is a subunit of protein phosphatase 1 (PP1), and PKA can phosphorylate regulators of PP1, potentially enhancing the activity of phostensin. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium, which can modulate calcium-dependent protein phosphatases such as PP1, to which phostensin binds, indirectly enhancing its regulatory function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation levels within the cell. This can indirectly enhance the regulatory role of phostensin on PP1 activity by preventing dephosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, indirectly increasing the functional activity of phostensin by reducing its substrate's dephosphorylation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation can result in enhanced phostensin activity through phosphorylation of PP1 or its regulatory subunits. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is another cell-permeable cAMP analog that activates PKA, which can phosphorylate components of the PP1 complex, potentially increasing phostensin activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a plethora of proteins, including PP1 regulatory subunits, possibly promoting phostensin's regulatory effects on PP1. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin inhibits PP1 and PP2A, which might enhance the regulatory role of phostensin in controlling PP1 activity by limiting dephosphorylation. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic Acid inhibits farnesyl pyrophosphate synthase leading to alterations in prenylation and potentially affecting PP1 localization and activity, thus indirectly influencing phostensin function. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Endothall acts as an inhibitor of PP1 and PP2A, like Cantharidin, and could enhance the activity of phostensin by maintaining phosphorylation states that phostensin regulates. | ||||||