phostensin Antibody (H-9): sc-376816
- phostensin Antibody (H-9) is a mouse monoclonal IgG1 κ phostensin antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 121-420 mapping within an internal region of phostensin of mouse origin
- phostensin Antibody (H-9) is recommended for detection of phostensin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-phostensin Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for phostensin Antibody (H-9) for WB applications. These reagents are now offered in bundles with phostensin Antibody (H-9) (see ordering information below).
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Phostensin Antibody (H-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects phostensin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-phostensin antibody (H-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Phostensin, also known as KIAA1949, is a 613 amino acid protein that plays a crucial role in cellular signaling by acting as a regulatory subunit for protein phosphatase 1 (PP1), which is essential for the dephosphorylation of serine and threonine residues on target proteins. This dephosphorylation process is vital for regulating numerous cellular functions, including cell division, homeostasis, and apoptosis. The interaction of phostensin with PP1 specifically targets this phosphatase to F-Actin within the cytoskeleton, thereby influencing cytoskeletal dynamics and cellular morphology. Phostensin is predominantly expressed in tissues such as the spleen, ovary, lung, and liver, and its two isoforms arise from alternative splicing events, which may contribute to its functional diversity in various cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
phostensin Antibody (H-9) References:
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. | Nagase, T., et al. 2001. DNA Res. 8: 319-27. PMID: 11853319
- Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. | Oliver, CJ., et al. 2002. Mol Cell Biol. 22: 4690-701. PMID: 12052877
- Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. | Terry-Lorenzo, RT., et al. 2002. J Biol Chem. 277: 46535-43. PMID: 12270929
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
- Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit. | Kao, SC., et al. 2007. Biochem Biophys Res Commun. 356: 594-8. PMID: 17374523
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
phostensin Antibody (H-9) | sc-376816 | 200 µg/ml | $316.00 | |||
phostensin Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-529939 | 200 µg Ab; 10 µg BP | $354.00 | |||
phostensin Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-523104 | 200 µg Ab, 40 µg BP | $354.00 | |||
phostensin Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-543775 | 200 µg Ab; 20 µg BP | $354.00 | |||
phostensin Antibody (H-9) AC | sc-376816 AC | 500 µg/ml, 25% agarose | $416.00 | |||
phostensin Antibody (H-9) HRP | sc-376816 HRP | 200 µg/ml | $316.00 | |||
phostensin Antibody (H-9) FITC | sc-376816 FITC | 200 µg/ml | $330.00 | |||
phostensin Antibody (H-9) PE | sc-376816 PE | 200 µg/ml | $343.00 | |||
phostensin Antibody (H-9) Alexa Fluor® 488 | sc-376816 AF488 | 200 µg/ml | $357.00 | |||
phostensin Antibody (H-9) Alexa Fluor® 546 | sc-376816 AF546 | 200 µg/ml | $357.00 | |||
phostensin Antibody (H-9) Alexa Fluor® 594 | sc-376816 AF594 | 200 µg/ml | $357.00 | |||
phostensin Antibody (H-9) Alexa Fluor® 647 | sc-376816 AF647 | 200 µg/ml | $357.00 | |||
phostensin Antibody (H-9) Alexa Fluor® 680 | sc-376816 AF680 | 200 µg/ml | $357.00 | |||
phostensin Antibody (H-9) Alexa Fluor® 790 | sc-376816 AF790 | 200 µg/ml | $357.00 |