Peroxin 16 Activators
Peroxin 16 activators predominantly comprise compounds that engage with the peroxisome proliferator-activated receptor (PPAR) family. Activation of PPARs is a known trigger for the proliferation of peroxisomes within the cell, which is intimately linked to the increased expression and functionality of peroxins, including PEX16. This class of chemicals does not activate PEX16 directly but does so by promoting the biogenesis of the organelles that PEX16 is crucial for assembling and maintaining.
PPAR agonists like Pioglitazone, Bezafibrate, Fenofibrate, and Rosiglitazone act through the activation of PPAR-γ or PPAR-α receptors, which leads to the transcription of genes involved in peroxisome proliferation, thereby increasing the cellular demand for PEX16. Such agonists stimulate the nuclear receptors to bind to PPAR response elements (PPREs) within the promoter regions of target genes, enhancing the expression of a myriad of proteins, including those related to peroxisome biogenesis. Compounds such as WY-14643 and Tetradecylthioacetic Acid, which are synthetic and natural PPAR agonists respectively, also modulate peroxisomal gene expression, suggesting an increase in PEX16 activity through enhanced peroxisome formation and maintenance. GW7647 and L-165041, through their action on PPAR-α and PPAR-δ, demonstrate the ability to influence the cellular processes that demand PEX16 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
A PPAR-γ agonist that promotes peroxisome proliferation, which can lead to increased expression and activity of PEX16 in peroxisome biogenesis. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
A PPAR agonist that can stimulate peroxisome proliferation, possibly enhancing PEX16-mediated peroxisome biogenesis. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Another PPAR agonist, historically used to lower lipid levels, which could increase peroxisome numbers and indirectly upregulate PEX16. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
Binds to the PPAR-α receptor and may promote peroxisomal proliferation, indirectly increasing PEX16 function. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
By activating PPAR-α, it can enhance the biogenesis of peroxisomes, potentially increasing the demand for PEX16. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A PPAR-γ agonist that can induce peroxisome proliferation and thus may increase PEX16 activity. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
An agonist for PPAR-α that can induce peroxisome proliferation, potentially leading to increased PEX16 expression and activity. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
A potent PPAR-α agonist, which could indirectly stimulate PEX16 activity by promoting peroxisome proliferation. | ||||||
GW6471 | 880635-03-0 | sc-300779 | 5 mg | $295.00 | 9 | |
As a PPAR-α antagonist, it can modulate PPAR-α activity and may indirectly affect PEX16 expression by altering peroxisomal metabolism. | ||||||
L-165041 | 79558-09-1 | sc-203094 | 5 mg | $156.00 | ||
A selective PPAR-δ agonist, potentially increasing peroxisome numbers and indirectly PEX16 function. | ||||||