Peroxin 16 Antibody (H-4): sc-398189

Peroxin 16 Antibody (H-4) is a mouse monoclonal IgM antibody that detects Peroxin 16 (PEX16) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Peroxin 16 antibody (H-4) is available as the non-conjugated form. Peroxisomes, which are single-membrane-bound organelles found in nearly all eukaryotic cells, play a vital role in various metabolic processes, including the beta-oxidation of very long-chain fatty acids and the detoxification of hydrogen peroxide. The Peroxin gene family, comprising over 20 members, is essential for the biogenesis of these organelles, with PEX16 being a multi-membrane protein consisting of 336 amino acids that is crucial for the formation and maintenance of peroxisomes. Notably, PEX16 interacts with other proteins involved in peroxisome assembly, such as PEX3 and PEX19, which are essential for the import of peroxisomal membrane proteins. Deficiencies in the gene encoding PEX16 can lead to severe peroxisome-related disorders, including Zellweger syndrome, neonatal adrenoleukodystrophy, infantile Refsum disease, classical rhizomelic chondrodysplasia punctata, and peroxisome biogenesis disorder complementation group 9. Peroxin 16 (H-4) antibody′s ability to effectively detect this critical protein makes it an invaluable tool for research into peroxisomal function and associated diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Peroxin 16 Antibody (H-4) References:

1. A novel aberrant splicing mutation of the PEX16 gene in two patients with Zellweger syndrome.  |  Shimozawa, N., et al. 2002. Biochem Biophys Res Commun. 292: 109-12. PMID: 11890679
2. Arabidopsis peroxin 16 coexists at steady state in peroxisomes and endoplasmic reticulum.  |  Karnik, SK. and Trelease, RN. 2005. Plant Physiol. 138: 1967-81. PMID: 16040658
3. The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER.  |  Kim, PK., et al. 2006. J Cell Biol. 173: 521-32. PMID: 16717127
4. The ER-peroxisome connection in plants: development of the 'ER semi-autonomous peroxisome maturation and replication' model for plant peroxisome biogenesis.  |  Mullen, RT. and Trelease, RN. 2006. Biochim Biophys Acta. 1763: 1655-68. PMID: 17049631
5. Arabidopsis peroxin 16 trafficks through the ER and an intermediate compartment to pre-existing peroxisomes via overlapping molecular targeting signals.  |  Karnik, SK. and Trelease, RN. 2007. J Exp Bot. 58: 1677-93. PMID: 17431024
6. [Human peroxisome-deficient disorders and pathogenic gene].  |  Fujiki, Y. 1994. Rinsho Shinkeigaku. 34: 1219-21. PMID: 7539728
7. Phenotype of patients with peroxisomal disorders subdivided into sixteen complementation groups.  |  Moser, AB., et al. 1995. J Pediatr. 127: 13-22. PMID: 7541833
8. [Clinical and molecular aspects of peroxisome-deficient disorders].  |  Suzuki, Y., et al. 1993. Nihon Rinsho. 51: 2353-8. PMID: 7692118
9. A unified nomenclature for peroxisome biogenesis factors.  |  Distel, B., et al. 1996. J Cell Biol. 135: 1-3. PMID: 8858157

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Peroxin 16 Antibody (H-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Peroxin 16 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Peroxin 16 Antibody (H-4) Specifications

Alternate Product Name: Peroxin 16

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 281-306

Epitope Target: Peroxin 16

Epitope Species: human

Product Reactivity/Detection: Peroxin 16

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Peroxin 16 Antibody (H-4): P: Blocking Peptide