LTB4 (Leukotriene B4) (CAS 71160-24-2)
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LTB4 (Leukotriene B4) is a potent, eicosanoid lipid mediator that plays numerous roles in inflammation, immunological functions and maintenance of biological homeostasis. Leukotrienes like LTB4 primarily act through specific G protein-coupled receptors. LTB4 has been found in myeloid cells and is biosynthesized from arachidonic acid. It may act to stimulate leukocyte functions including chemokinesis, chemotaxis, lysosomal enzyme release, superoxide anion production, adhesion to endothelial cells, C3b receptor expression, CD11b up-regulation, generation of ROS, induction of the IL-2 receptor and IL-2 production. The chemokine has also been observed to enhance activation, proliferation and differentiation of human B-lymphocytes, T-lymphoctes, granulocytes, macrophages, monocytes, esinophils, and NK cells. In the nervous system and the brain, LTB4 is involved in the modulation of the ryanodine receptor and the activation of the capsaicin receptor. It is involved in melanocyte pigmentation. Additionally, it has been found to attenuate inflammation through binding of orphan receptor PPARα.
LTB4 (Leukotriene B4) (CAS 71160-24-2) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTB4 (Leukotriene B4), 50 µg | sc-201043 | 50 µg | $367.00 |