Molecular structure of GW6471, CAS Number: 880635-03-0
GW6471 (CAS 880635-03-0)
See product citations (9)
Application:
GW6471 is a complete inhibitor of PPARα that allows interaction with co-repressors
CAS Number:
880635-03-0
Molecular Weight:
619.67
Molecular Formula:
C35H36F3N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW6471 is a PPARalpha antagonist, shown to completely inhibit GW409544-induced activation of PPARalpha. GW6471 induces a PPARalpha conformation that interacts efficiently with co-repressors. GW6471 is an imidazopyridine-based synthetic compound widely used in scientific research for its ability to regulate the activity of different biological pathways. It may act to inhibit the PI3K/Akt/mTOR pathway, which is responsible for controlling cell growth and proliferation, and the NF-kB pathway, which regulates inflammation and immune responses.
GW6471 (CAS 880635-03-0) References
- Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells. | Florio, R., et al. 2018. Sci Rep. 8: 13610. PMID: 30206358
- Formononetin protects against cisplatin‑induced acute kidney injury through activation of the PPARα/Nrf2/HO‑1/NQO1 pathway. | Hao, Y., et al. 2021. Int J Mol Med. 47: 511-522. PMID: 33416097
- PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress. | Castelli, V., et al. 2021. Biomedicines. 9: PMID: 33525605
- Mitochondria damage in ambient particulate matter induced cardiotoxicity: Roles of PPAR alpha/PGC-1 alpha signaling. | Jiang, Q., et al. 2021. Environ Pollut. 288: 117792. PMID: 34280742
- Low-dose mono(2-ethylhexyl) phthalate promotes ovarian cancer development through PPARα-dependent PI3K/Akt/NF-κB pathway. | Leng, J., et al. 2021. Sci Total Environ. 790: 147990. PMID: 34380243
- An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. | Duan, X., et al. 2021. Cell Rep. 37: 109920. PMID: 34731648
- Physospermum cornubienseL. alleviates nociceptive and neuropathic pain: Evidences and possible mechanisms. | Khoei, HA., et al. 2022. J Ethnopharmacol. 114957. PMID: 34995691
- Palmitoylethanolamide Promotes White-to-Beige Conversion and Metabolic Reprogramming of Adipocytes: Contribution of PPAR-α. | Annunziata, C., et al. 2022. Pharmaceutics. 14: PMID: 35214069
- Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary. | Meling, DD., et al. 2022. Reprod Toxicol. 110: 113-123. PMID: 35421560
- Resveratrol blocks retrotransposition of LINE-1 through PPAR α and sirtuin-6. | Okudaira, N., et al. 2022. Sci Rep. 12: 7772. PMID: 35546166
- Hepatocyte Thorns, A Novel Drug-Induced Stress Response in Human and Mouse Liver Spheroids. | Pridgeon, CS., et al. 2022. Cells. 11: PMID: 35626634
- Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway. | Gu, Y., et al. 2022. Phytomedicine. 103: 154219. PMID: 35691075
- Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro. | Wang, N., et al. 2022. Int Immunopharmacol. 111: 109058. PMID: 35901530
- Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis. | Yao, M., et al. 2022. Front Pharmacol. 13: 935937. PMID: 36081929
Inhibitor of:
ABCD1, AdipoR1, APBB1IP, APOBEC4, EG329055, mPRε, Peroxin 13, Peroxin 3, PPARα, and Pxmp2.Activator of:
AMPKα1, ARK5, ChREBP, and Peroxin 16.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW6471, 5 mg | sc-300779 | 5 mg | $295.00 |