Per 1 Inhibitors
Chemical inhibitors of Period circadian protein homolog 1 (Per 1) encompass a range of molecules that interfere with various signaling pathways and cellular processes regulated by this protein. Axitinib can inhibit the vascular endothelial growth factor receptors, which are involved in pathways where Per 1 plays a regulatory role. By doing so, axitinib can diminish the downstream effects of Per 1-mediated signaling. Similarly, rapamycin, as an mTOR inhibitor, can suppress cellular processes that Per 1 influences, particularly those related to cell growth and proliferation. LY294002, a phosphatidylinositol 3-kinase inhibitor, can downregulate AKT activity and therefore can disrupt PI3K/AKT signaling pathways regulated by Per 1. Additionally, the ROCK inhibitor Y-27632 can impede the function of Rho-associated protein kinase, potentially disrupting actin cytoskeleton regulation where Per 1 is implicated.
Further exploring the chemical inhibition of Per 1, PD0325901 and U0126, both targeting the MEK pathway, can block the MAPK/ERK pathway which is associated with the regulatory functions of Per 1. SB203580 specifically inhibits p38 MAPK, thereby can influence stress response pathways involving Per 1. SP600125, as a JNK inhibitor, can hinder regulatory capacities of Per 1 in apoptosis and cellular proliferation. Wortmannin, another PI3K inhibitor, leads to the downregulation of AKT, further emphasizing the inhibition of Per 1's functionality. ZM-447439 targets Aurora kinases and can interfere with Per 1's role in cell cycle regulation. Roscovitine, a CDK inhibitor, can disrupt the cell cycle control where Per 1 is active. Lastly, dasatinib, a Src family kinase inhibitor, can obstruct Src kinase-related pathways, where Per 1 exerts its regulatory effects, leading to a broad inhibition of Per 1's influence in cellular signaling events.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor known to suppress cell growth and proliferation. Since Per 1 plays a role in cell cycle regulation, rapamycin may diminish Per 1's influence on cell cycle progression by inhibiting mTOR signaling pathways that Per 1 is known to be involved in. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Per 1 is linked with the regulation of PI3K/AKT signaling, and the inhibition of PI3K by LY294002 will downregulate AKT activity, thereby potentially inhibiting the pathways regulated by Per 1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that impedes the function of Rho-associated protein kinase. As Per 1 has been associated with the regulation of actin cytoskeleton through Rho GTPases, Y-27632 can disrupt signaling pathways that Per 1 may regulate. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which may inhibit the stress response pathways that Per 1 has been implicated in. By inhibiting p38 MAPK, SB203580 could reduce Per 1's role in mediating cellular responses to stress. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which has been linked to the regulation of apoptosis and cellular proliferation. Since Per 1 can influence these processes, inhibition of JNK by SP600125 could hinder Per 1's regulatory capacity in these contexts. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream regulators of ERK1/2. As Per 1 has been shown to be involved in the regulation of the MEK/ERK pathway, the inhibition by U0126 could suppress the activity of Per 1-regulated processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible PI3K inhibitor. Inhibition of PI3K by Wortmannin would lead to the downregulation of AKT, a pathway that Per 1 is known to influence, thereby potentially inhibiting Per 1's functionality in cellular processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Per 1 has been implicated in the regulation of cell cycle and mitosis, and inhibition of Aurora kinase by ZM-447439 may interfere with these processes, thus potentially inhibiting Per 1's role in cell cycle regulation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a cyclin-dependent kinase (CDK) inhibitor that may disrupt the cell cycle, where Per 1 is known to have regulatory functions. By inhibiting CDKs, Roscovitine could impede the cell cycle-related activities of Per 1. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor. Src kinase activity has been associated with multiple cellular pathways, including those regulated by Per 1. By inhibiting Src kinases, Dasatinib might obstruct the pathways where Per 1 exerts its effects. | ||||||