PEF Activators
PEF Activators encompass a range of chemicals that can influence the activity of PEF, also known as PEF1, a protein intricately linked with calcium-binding functions. Given its association with calcium, a significant fraction of chemicals classified as PEF Activators focuses on modulating intracellular calcium levels, subsequently influencing the activity and function of PEF1.
Calcium ions, central to a myriad of cellular processes, play a pivotal role in the context of PEF activators. Agents like thapsigargin elevate cytosolic calcium levels by inhibiting the sarco/endoplasmic reticulum Ca^2+-ATPase (SERCA), indirectly influencing PEF1's activity. Similarly, ionomycin, a calcium ionophore, increases intracellular calcium concentrations, thereby affecting PEF1. Ryanodine, by modulating calcium release from the sarcoplasmic reticulum, and BAPTA-AM, a cell-permeable calcium chelator, are other notable agents that can alter the cellular calcium landscape, subsequently impacting PEF1's function. Furthermore, chemicals like caffeine, which modify calcium release from internal stores, and 2-Aminoethoxydiphenyl borate (2-APB), which alters intracellular calcium levels, can also influence PEF1. On the other hand, calcium channel blockers like nifedipine and verapamil modulate calcium entry into cells, indirectly affecting PEF1's calcium-binding function. EGTA, a potent calcium chelator, and cyclopiazonic acid, a SERCA inhibitor, represent other agents that through their actions on calcium homeostasis can indirectly modulate PEF1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
As PEF1 is related to calcium-binding, altering intracellular calcium concentrations can indirectly influence PEF1's activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin elevates cytosolic calcium levels by inhibiting the sarco/endoplasmic reticulum Ca^2+-ATPase (SERCA). This can indirectly modulate PEF1's calcium-binding function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
It's a calcium ionophore that increases intracellular calcium levels, which can indirectly influence PEF1 activity. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Modulates calcium release from the sarcoplasmic reticulum and can indirectly impact PEF1 through changes in calcium signaling. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A cell-permeable calcium chelator. By sequestering calcium, it can indirectly influence PEF1's calcium-binding function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Modulates calcium release from internal stores, indirectly affecting calcium-dependent proteins like PEF1. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Modifies intracellular calcium levels, potentially impacting PEF1. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
A calcium channel blocker. By modulating calcium entry into the cell, it can indirectly affect calcium-binding proteins like PEF1. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
A calcium chelator. By binding to calcium, it can indirectly impact the function of PEF1. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Inhibits the sarco/endoplasmic reticulum Ca^2+-ATPase (SERCA), leading to changes in calcium homeostasis, which can influence PEF1. | ||||||