PED7A Activators
PED7A activators are a set of chemical entities that function through various intracellular signaling mechanisms to indirectly amplify the activity of PED7A. Compounds like Forskolin, Isoproterenol, and Vasoactive Intestinal Peptide elevate cAMP levels, leading to the activation of PKA, which potentially phosphorylates and enhances PED7A activity if it is a cAMP-PKA pathway participant. Similarly, direct PKA activators such as 8-Bromo-cAMP bypass the requirement for upstream adenylyl cyclase activation, offering a direct route to PED7A activation. Additionally, Sildenafil and IBMX maintain elevated cAMP and cGMP levels by inhibiting their degradation, leading to sustained PKA activity which could enhance PED7A activity. On another front, PMA and Capsaicin, through the activation of PKC and TRPV1 respectively, could lead to the phosphorylation of PED7A within PKC-regulated or calcium-dependent pathways.
Furthermore, molecules such as Ionomycin and A23187 increase intracellular calcium levels, which may activate calcium-dependent kinases that could phosphorylate PED7A, enhancing its activity. Nicotinic Acid, although it initially inhibits adenylyl cyclase, could sensitize the cAMP pathway to subsequent activation, resulting in an indirect enhancement of PED7A activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels in the cell. Elevated cAMP activates PKA, which can phosphorylate various proteins including PED7A, thereby enhancing PED7A's activity if it is cAMP-PKA pathway-dependent. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to phosphorylation of PED7A if PED7A is a substrate of PKC or is involved in a PKC-regulated pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases, which may directly enhance the activity of PED7A if it is regulated by calcium signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that activates adenylyl cyclase through G protein-coupled receptor signaling, increasing cAMP and subsequently activating PKA. PKA may then phosphorylate and enhance PED7A activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore, similar to Ionomycin. It also increases intracellular calcium, potentially activating PED7A through calcium-dependent pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This compound is a cell-permeable cAMP analog that directly activates PKA without the need for adenylyl cyclase activation, potentially enhancing PED7A activity if it is cAMP-PKA responsive. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, increasing levels of cAMP and cGMP by preventing their degradation, which could activate PKA and enhance PED7A activity. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic acid, or niacin, acts through G protein-coupled receptors to inhibit adenylyl cyclase indirectly. While this typically reduces cAMP, the negative feedback can sensitize the pathway, potentially leading to enhanced activity of PED7A upon reactivation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that inhibits various protein kinases and could enhance PED7A activity by shifting the balance of kinase activity within a relevant signaling network that includes PED7A. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates the TRPV1 receptor, which can lead to an influx of calcium ions, thereby potentially enhancing PED7A activity if PED7A is regulated by calcium-dependent signaling pathways. | ||||||