PCDHB6 Inhibitors
Inhibitors of PCDHB6 function by intervening in critical signaling pathways and cellular processes that regulate cell adhesion and communication. For instance, certain inhibitors target protein kinase C (PKC), which phosphorylates substrates including cell adhesion molecules, thereby modifying their function and potentially leading to a reduction in the adhesive capabilities of PCDHB6. Other inhibitors work by interfering with the calcium signaling that is fundamental to the regulation of cell adhesion, either through chelation of intracellular calcium or by blocking calcium channels and receptors. These actions disrupt the calcium-dependent processes that PCDHB6 may rely on for proper function, thereby diminishing its role in cell-cell adhesion. Some compounds exert their inhibitory effects by stabilizing the actin cytoskeleton, hence affecting the organizational structure that PCDHB6 depends on to mediate cell adhesion and communication.
Additionally, there are inhibitors that modulate gene expression by altering the chromatin structure surrounding the PCDHB6 gene, which could result in decreased expression of this protein. The inhibition of specific kinases involved in the ERK/MAPK and PI3K/Akt pathways can also lead to changes in the expression or activity of cell adhesion molecules, including PCDHB6. By impeding the processes that govern cytoskeletal organization, lamellipodia formation, and cell migration, these inhibitors directly or indirectly impact the functional activity of PCDHB6. Furthermore, the inhibition of proteases and phosphatases that play a role in post-translational modifications of cell adhesion proteins may also contribute to the decreased functional activity of PCDHB6.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A potent activator of protein kinase C (PKC), which can phosphorylate PCDHB6, leading to altered cell adhesion and potentially down-regulating PCDHB6's adhesive functions. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
A calpain inhibitor that prevents the cleavage of substrates by calpain proteases. By inhibiting calpain, the post-translational processing of PCDHB6 could be altered, thus reducing its functional activity. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
A calmodulin antagonist that inhibits calcium-calmodulin dependent processes. Since PCDHB6 may be regulated by calcium signaling, this inhibition can reduce PCDHB6-mediated adhesion. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that can alter gene expression patterns, potentially reducing the expression of PCDHB6 by changing the chromatin structure around the PCDHB6 gene. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK which indirectly affects the ERK/MAPK pathway. Downstream effects of this pathway may include alterations in cell adhesion molecules such as PCDHB6, leading to decreased function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor which can affect the PI3K/Akt pathway, potentially leading to changes in cell survival and adhesion mechanisms involving PCDHB6. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that can impair actin cytoskeleton organization. Since PCDHB6 is implicated in cell-cell adhesion, disrupting the cytoskeleton could decrease PCDHB6's adhesive function. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
A Rac1 inhibitor which may impair lamellipodia formation and cell migration, processes that PCDHB6 could be involved in, thus reducing its functional role in cell-cell adhesion. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A calcium chelator that reduces intracellular calcium levels, potentially affecting calcium-dependent adhesion processes mediated by PCDHB6. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Inhibits calcineurin, which may affect the dephosphorylation of proteins involved in cell adhesion, including PCDHB6, leading to reduced adhesion function. | ||||||