PCDH15_Pcdh15 Activators
PCDH15_Pcdh15 activators are compounds that would interact with the protein PCDH15, also known as Protocadherin-15, which is a member of the cadherin superfamily and plays a significant role in the establishment and maintenance of specialized cell-cell contacts in sensory epithelia, including retinal photoreceptors and hair cells in the inner ear. While PCDH15 is not an enzyme with catalytic activity that can be traditionally activated in the biochemical sense, these activators would be designed to modulate the function of PCDH15 either by enhancing its natural protein-protein interactions or by stabilizing its structure and presence at cell junctions.
Direct activators of PCDH15 would likely bind to the protein and induce conformational changes that promote its adhesive interactions or stabilize its homophilic binding, which is the ability of identical molecules to attach to each other. This could increase the strength of cellular adhesion mediated by PCDH15 or could potentiate its interaction with cytoplasmic binding partners and associated signaling pathways. Indirect activators, in contrast, might influence the expression levels, localization, or post-translational modifications of PCDH15. For instance, a chemical that upregulates the transcription of the PCDH15 gene would result in an increased production of the protein, enhancing its cellular functions. Other indirect activators could prevent the proteolytic degradation of PCDH15, alter its glycosylation patterns, or affect the composition of the lipid microdomains where PCDH15 is localized, thereby modulating its activity within the cell.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC activation can lead to downstream signaling events. If PCDH15 is a part of the PKC pathway or is regulated by the PKC pathway, upregulation of PKC activity by PMA can enhance the expression or function of PCDH15. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases the intracellular levels of cAMP, leading to the activation of protein kinase A (PKA). If PCDH15 is a part of the PKA pathway or regulated by it, Forskolin can enhance the expression or function of PCDH15. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the insulin receptor pathway. If PCDH15 is a part of the insulin receptor pathway or regulated by it, Insulin can enhance the expression or function of PCDH15. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
Glucose can activate several signal transduction pathways related to metabolism. If PCDH15 is involved in these pathways or regulated by them, glucose can enhance the expression or function of PCDH15. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is a ligand for the retinoic acid receptor (RAR). By modulating gene expression via the RAR, it can enhance the transcription of PCDH15 if it is a target of RAR. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA acts as a signaling molecule and activates the LPA receptor pathway. If PCDH15 is a part of the LPA receptor pathway or regulated by it, LPA can enhance the expression or function of PCDH15. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist. If PCDH15 is a part of the adrenergic receptor pathway or regulated by it, Isoproterenol can enhance the expression or function of PCDH15. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate is a histone deacetylase (HDAC) inhibitor. By promoting the acetylation of histones, Sodium Butyrate can enhance the accessibility of transcription factors to the promoter region of PCDH15 and increase its transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. By preventing DNA methylation, 5-Azacytidine can enhance the expression of PCDH15 if its promoter region is normally methylated. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation. If PCDH15 is a target of mTOR, Rapamycin can enhance the expression of PCDH15 in response to mTOR inhibition. | ||||||