PAT3 Activators
PAT3 activators encompass a variety of compounds that influence intracellular signaling cascades and cellular processes, potentially leading to increased functional activity of the protein. One such mechanism is the modulation of intracellular cAMP levels. Compounds that elevate cAMP act as secondary messengers in various signal transduction pathways and could enhance PAT3 activity if it is regulated by cAMP-dependent protein kinase A (PKA) or exchange protein activated by cAMP (EPAC). Similarly, agents that raise intracellular calcium levels might activate PAT3 by engaging calcium-dependent proteins and enzymes, which might interact with or modify PAT3.
Another activation mechanism involves kinase signaling pathways. Certain molecules have the ability to activate kinases such as PKC or PI3K/Akt, which can lead to phosphorylation events. If PAT3 is a direct substrate of these kinases or if its activity is modulated by downstream effectors in these pathways, these molecules could increase PAT3 activity. Additionally, modulation of lipid signaling pathways or inhibition of phosphodiesterases, which prevent the breakdown of cAMP, can have an indirect effect on the activation state of PAT3. Other molecules might influence gene expression through interaction with nuclear receptors, which could lead to an increase in PAT3 activity if it is regulated by such transcriptional mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates intracellular cAMP levels by activating adenylate cyclase. Increased cAMP may enhance PAT3 activity if PAT3 is regulated by cAMP-dependent pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC). PKC-mediated phosphorylation could lead to the activation of PAT3 if it is a substrate of PKC or if PKC regulates a pathway influencing PAT3 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels. If PAT3 is calcium-sensitive or part of a calcium-dependent signaling pathway, ionomycin may enhance its activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Activates the PI3K/Akt signaling pathway. If PAT3 is downstream of Akt, insulin could increase PAT3 activity through phosphorylation events or secondary messengers. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
Sphingosine-1-phosphate receptor modulator. It may amplify PAT3 activity if PAT3 is modulated by sphingolipid signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Beta-adrenergic receptor agonist that can increase cAMP levels, potentially enhancing PAT3 activity if linked to beta-adrenergic signaling. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Donates nitric oxide which can activate soluble guanylyl cyclase, increasing cGMP levels. If PAT3 is cGMP-responsive, its activity may be increased. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
A cAMP analog that resists degradation. Enhances cAMP-dependent processes, potentially activating PAT3 if it is regulated by these pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Inhibits phosphodiesterases, preventing cAMP breakdown. This could result in increased PAT3 activity if PAT3 operates within cAMP-dependent signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3, potentially leading to the activation of Wnt signaling. If PAT3 is associated with this pathway, lithium may indirectly increase its activity. | ||||||