Date published: 2025-12-6

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PAR-2 Activators

PAR-2 Activators are a chemical class that can either directly or indirectly act on the PAR-2 protein. Direct activators, such as trypsin and thrombin, cleave the N-terminus of PAR-2, producing a tethered ligand that activates the protein. This class of chemicals can activate PAR-2 without the need for external factors, making them primary activators of the protein. Serine proteases, which include trypsin and thrombin, feature prominently in this category. Indirect activators, on the other hand, influence the cellular processes or signaling pathways that PAR-2 is involved in. These chemicals do not interact with the protein directly, but their action can lead to the protein's activation. Chlorogenic acid and forskolin, for example, increase cAMP levels, which can activate PAR-2. Similarly, histamine, bradykinin, and prostaglandin E2 act by increasing intracellular calcium, a secondary messenger in the PAR-2 pathway. Dithiothreitol can alter the protein conformation of PAR-2 and indirectly activate its pathway. PIP2 acts as a substrate for producing secondary messengers in the PAR-2 pathway, and calcium ions serve as a secondary messenger themselves.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SLIGRL-NH2

171436-38-7sc-359903
1 mg
$82.00
(1)

SLIGRL-NH2 (CAS 171436-38-7) is a synthetic peptide that can directly activate the PAR-2 protein. It mimics the tethered ligand produced when PAR-2 is cleaved by proteases. The peptide binds to the protein, triggering intracellular signaling and facilitating the protein's biological functions.

2-Furoyl-LIGRLO-amide trifluoroacetate salt

729589-58-6 (non-salt)sc-213814
1 mg
$148.00
1
(1)

2-Furoyl-LIGRLO-amide trifluoroacetate salt (CAS 729589-58-6) is a synthetic peptide and activator of PAR-2. The compound interacts with the protein in a manner akin to the endogenous agonist, binding to the receptor, and initiating intracellular signaling, thus activating the protein's biological functions.

AC 55541

916170-19-9sc-203799
sc-203799A
5 mg
25 mg
$132.00
$520.00
2
(0)

AC 55541 (CAS 916170-19-9) is a potent and selective agonist of PAR-2. It can directly bind to and activate the protein, resulting in the initiation of intracellular signaling pathways. This leads to the facilitation of PAR-2's biological functions without the need for proteolytic cleavage of the receptor.

AC 264613

1051487-82-1sc-358026
sc-358026A
10 mg
50 mg
$243.00
$1000.00
(0)

AC 264613 (CAS 1051487-82-1) is a selective agonist of PAR-2. It can directly bind to and activate the protein, initiating intracellular signaling pathways associated with the protein's biological functions. Unlike proteases, AC 264613 activates PAR-2 without the need for proteolytic cleavage of the receptor.

Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt

171436-38-7 (non-salt)sc-301799
1 mg
$77.00
(1)

Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt (CAS 171436-38-7) is a synthetic peptide that operates as a direct activator of PAR-2. It mimics the action of the receptor's tethered ligand, binding to it and initiating intracellular signaling. This interaction facilitates the biological functions of the PAR-2 protein without requiring protease-mediated cleavage.

Chlorogenic Acid

327-97-9sc-204683
sc-204683A
500 mg
1 g
$46.00
$68.00
1
(1)

Chlorogenic Acid can inhibit phosphodiesterase, leading to increased cAMP, which can indirectly activate the PAR-2 pathway.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin can increase cAMP levels, indirectly activating the PAR-2 pathway.

Histamine, free base

51-45-6sc-204000
sc-204000A
sc-204000B
1 g
5 g
25 g
$92.00
$277.00
$969.00
7
(1)

Histamine can indirectly activate PAR-2 through an increase in intracellular calcium, a secondary messenger in the PAR-2 pathway.

Bradykinin

58-82-2sc-507311
5 mg
$110.00
(0)

Bradykinin can indirectly activate PAR-2 through its action on bradykinin receptors, leading to increased intracellular calcium, a secondary messenger in the PAR-2 pathway.

PGE2

363-24-6sc-201225
sc-201225C
sc-201225A
sc-201225B
1 mg
5 mg
10 mg
50 mg
$56.00
$156.00
$270.00
$665.00
37
(1)

Prostaglandin E2 can indirectly activate PAR-2 by increasing intracellular calcium, a secondary messenger in the PAR-2 pathway.