AC 264613 CAS: 1051487-82-1
MF: C19H18BrN3O2
MW: 400.27
A potent and selective protease-activated receptor 2 agonist.

AC 264613 (CAS 1051487-82-1)

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Alternate Names: (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide
Application: AC 264613 is a potent and selective protease-activated receptor 2 agonist
CAS Number: 1051487-82-1
Molecular Weight: 400.27
Molecular Formula: C19H18BrN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

AC 264613 is a selective and potent PAR2 ( protease-activated receptor 2) agonist. Additionally, AC 264613 is noted to display no activity towards other PAR subtypes or at other receptors implicated in nociception and inflammation. Other reports have indicated that phosphatidylinositol hydrolysis (PI), moblization of Ca2+ and cellular proliferation in cell cultures are stimulated by AC 264613.


References

1. Seitzberg, J.G., et al. 2008. J. Med. Chem. 51: 5490-5493. PMID: 18720984
2. Gardell, L.R., et al. 2008. J. Pharmacol. Exp. Ther. 327: 799-808. PMID: 18768780

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at -20° C
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
PAR-2: EC5050 = 31.62 nM (human)
pK Values :
pKa: 10.5 (Predicted), pKb: 0.39 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25108343
MDL Number :
MFCD18086869
SMILES :
C/C(=NNC(=O)[[email protected]@H]1[[email protected]](CNC1=O)C2=CC=CC=C2)/C3=CC(=CC=C3)Br

Download SDS (MSDS)

Certificate of Analysis

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