Molecular structure of AC 264613, CAS Number: 1051487-82-1
AC 264613 (CAS 1051487-82-1)
Alternate Names:
(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide
Application:
AC 264613 is a potent and selective protease-activated receptor 2 agonist
CAS Number:
1051487-82-1
Molecular Weight:
400.27
Molecular Formula:
C19H18BrN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AC 264613 is a selective and potent PAR2 (protease-activated receptor 2) agonist. Additionally, AC 264613 is noted to display no activity towards other PAR subtypes or at other receptors implicated in nociception and inflammation. Other reports have indicated that phosphatidylinositol hydrolysis (PI), moblization of Ca2+ and cellular proliferation in cell cultures are stimulated by AC 264613.
AC 264613 (CAS 1051487-82-1) References
- Discovery of potent and selective small-molecule PAR-2 agonists. | Seitzberg, JG., et al. 2008. J Med Chem. 51: 5490-3. PMID: 18720984
- Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. | Gardell, LR., et al. 2008. J Pharmacol Exp Ther. 327: 799-808. PMID: 18768780
- Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2. | Gan, J., et al. 2011. Br J Pharmacol. 163: 984-94. PMID: 21366553
- The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. | Jensen, DD., et al. 2013. J Biol Chem. 288: 22942-60. PMID: 23818521
- The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists. | Ma, JN. and Burstein, ES. 2013. J Pharmacol Exp Ther. 347: 697-704. PMID: 24078870
- Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter. | Tanaka, Y., et al. 2015. Eur J Pharmacol. 752: 97-105. PMID: 25701722
- Protease-Activated Receptor-2 Up-Regulates Transient Receptor Potential Vanilloid 4 Function in Mouse Esophageal Keratinocyte. | Suzuki, N., et al. 2015. Dig Dis Sci. 60: 3570-8. PMID: 26233549
- A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. | Yamaguchi, R., et al. 2016. Cell Biol Int. 40: 629-41. PMID: 26833899
- Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2. | Lieu, T., et al. 2016. Br J Pharmacol. 173: 2752-65. PMID: 27423137
- Stereoselective Synthesis of α-Fluoro-γ-nitro Thioesters under Organocatalytic Conditions. | Cosimi, E., et al. 2016. Org Lett. 18: 6014-6017. PMID: 27934387
- Differential regulation of IL-23 production in M1 macrophages by TIR8/SIGIRR through TLR4- or TLR7/8-mediated signaling. | Yamaguchi, R., et al. 2017. Cytokine. 99: 310-315. PMID: 28869081
- Molecular mechanisms regulating Proteinase-Activated Receptors (PARs). | Chandrabalan, A. and Ramachandran, R. 2021. FEBS J. 288: 2697-2726. PMID: 33742547
- Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines. | Moudio, S., et al. 2022. Psychopharmacology (Berl). 239: 229-242. PMID: 34888704
- Proteinase-activated receptors regulate intestinal functions in a segment-dependent manner in rats. | Mirakhur, M. and Diener, M. 2022. Eur J Pharmacol. 933: 175264. PMID: 36100127
Activator of:
PAR-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AC 264613, 10 mg | sc-358026 | 10 mg | $248.00 | |||
| US: Only available in the US | ||||||
AC 264613, 50 mg | sc-358026A | 50 mg | $1020.00 | |||
| US: Only available in the US | ||||||