Molecular structure of AC 55541, CAS Number: 916170-19-9
AC 55541 (CAS 916170-19-9)
See product citations (2)
Application:
AC 55541 is a selective protease-activated receptor 2 agonist
CAS Number:
916170-19-9
Purity:
≥98%
Molecular Weight:
518.36
Molecular Formula:
C25H20BrN5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in inflammation and nociception. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.
AC 55541 (CAS 916170-19-9) References
- Discovery of potent and selective small-molecule PAR-2 agonists. | Seitzberg, JG., et al. 2008. J Med Chem. 51: 5490-3. PMID: 18720984
- Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. | Gardell, LR., et al. 2008. J Pharmacol Exp Ther. 327: 799-808. PMID: 18768780
- The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists. | Ma, JN. and Burstein, ES. 2013. J Pharmacol Exp Ther. 347: 697-704. PMID: 24078870
- Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. | Tripathi, T., et al. 2014. Invest Ophthalmol Vis Sci. 55: 3912-21. PMID: 24876278
- Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias. | Homma, T., et al. 2016. Am J Respir Cell Mol Biol. 54: 60-70. PMID: 26072921
- Role of protease-activated receptors 2 (PAR2) in ocular infections and inflammation. | Tripathi, T. and Alizadeh, H. 2014. Receptors Clin Investig. 1: PMID: 26078987
- Potent Small Agonists of Protease Activated Receptor 2. | Yau, MK., et al. 2016. ACS Med Chem Lett. 7: 105-10. PMID: 26819675
- Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells. | Chao, HH., et al. 2017. J Biomed Sci. 24: 85. PMID: 29141644
- Inhibition of PAR-2 Attenuates Neuroinflammation and Improves Short-Term Neurocognitive Functions Via ERK1/2 Signaling Following Asphyxia-Induced Cardiac Arrest in Rats. | Ocak, U., et al. 2020. Shock. 54: 539-547. PMID: 32028357
- Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation. | Carey, RM., et al. 2020. J Biol Chem. 295: 6721-6740. PMID: 32241907
- The development of proteinase-activated receptor-2 modulators and the challenges involved. | McIntosh, KA., et al. 2020. Biochem Soc Trans. 48: 2525-2537. PMID: 33242065
- Molecular mechanisms regulating Proteinase-Activated Receptors (PARs). | Chandrabalan, A. and Ramachandran, R. 2021. FEBS J. 288: 2697-2726. PMID: 33742547
- Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach. | Pulakuntla, S., et al. 2021. Virusdisease. 32: 690-702. PMID: 34307771
- Meningitic Escherichia coli-Induced Interleukin-17A Facilitates Blood-Brain Barrier Disruption via Inhibiting Proteinase 3/Protease-Activated Receptor 2 Axis. | Xu, B., et al. 2022. Front Cell Neurosci. 16: 814867. PMID: 35221923
- TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis. | Wang, Y., et al. 2022. J Dermatol Sci. 106: 181-188. PMID: 35637111
Activator of:
PAR-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AC 55541, 5 mg | sc-203799 | 5 mg | $132.00 | |||
AC 55541, 25 mg | sc-203799A | 25 mg | $520.00 |