Molecular structure of Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt, CAS Number: 171436-38-7 (non-salt)
Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt (CAS 171436-38-7 (non-salt))
Alternate Names:
PAR-2 (1-6) amide (mouse, rat) trifluoroacetate salt
Application:
Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt is a selective PAR2 peptide agonist
CAS Number:
171436-38-7 (non-salt)
Molecular Weight:
770.84
Molecular Formula:
C31H57O9N10F3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Selective proteinase-activated receptor 2 (PAR2) peptide agonist.
Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt (CAS 171436-38-7 (non-salt)) References
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- Distinct roles for protease-activated receptors 1 and 2 in vasomotor modulation in rat superior mesenteric artery. | Kawabata, A., et al. 2004. Cardiovasc Res. 61: 683-92. PMID: 14985065
- Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity. | Kawabata, A., et al. 2004. J Pharmacol Exp Ther. 311: 402-10. PMID: 15199093
- Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. | Kawao, N., et al. 2005. J Pharmacol Exp Ther. 315: 576-89. PMID: 16120814
- PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts. | Jiang, R., et al. 2007. Am J Physiol Heart Circ Physiol. 293: H2845-52. PMID: 17720772
- Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. | Zhang, XC. and Levy, D. 2008. Cephalalgia. 28: 276-84. PMID: 18254896
- Involvement of capsaicin-sensitive afferent nerves in the proteinase-activated receptor 2-mediated vasodilatation in the rat dura mater. | Dux, M., et al. 2009. Neuroscience. 161: 887-94. PMID: 19362118
- Proteinase-activated receptor-2 (PAR2) and mouse osteoblasts: regulation of cell function and lack of specificity of PAR2-activating peptides. | Georgy, SR., et al. 2010. Clin Exp Pharmacol Physiol. 37: 328-36. PMID: 19769607
- Proteinase-activated receptor-2-triggered prostaglandin E(2) release, but not cyclooxygenase-2 upregulation, requires activation of the phosphatidylinositol 3-kinase/Akt / nuclear factor-kappaB pathway in human alveolar epithelial cells. | Moriyuki, K., et al. 2009. J Pharmacol Sci. 111: 269-75. PMID: 19881225
- Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms. | Fukushima, O., et al. 2010. J Neurosci Res. 88: 3198-205. PMID: 20806405
- The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice. | Nishimura, S., et al. 2010. Life Sci. 87: 643-50. PMID: 20932849
- Effect of diet-induced obesity on BK(Ca) function in contraction and dilation of rat isolated middle cerebral artery. | Howitt, L., et al. 2014. Vascul Pharmacol. 61: 10-5. PMID: 24576493
- Reply: Protease Plays a Role in Ragweed Pollen-Induced Neutrophil Recruitment and Epithelial Barrier Disruption. | Hosoki, K., et al. 2017. Am J Respir Cell Mol Biol. 56: 272-273. PMID: 28145773
- Protease-dependent excitation of nodose ganglion neurons by commensal gut bacteria. | Pradhananga, S., et al. 2020. J Physiol. 598: 2137-2151. PMID: 32134496
- Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine. | Kopruszinski, CM., et al. 2020. Cephalalgia. 40: 1535-1550. PMID: 33131305
Activator of:
PAR-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt, 1 mg | sc-301799 | 1 mg | $77.00 |