Molecular structure of SLIGRL-NH2, CAS Number: 171436-38-7
SLIGRL-NH2 (CAS 171436-38-7)
Alternate Names:
seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide
Application:
SLIGRL-NH2 is a PAR2-activating agonist peptide
CAS Number:
171436-38-7
Molecular Weight:
656.82
Molecular Formula:
C29H56N10O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SLIGRL-NH2 is a PAR2-activating peptide. SLIGRL-NH2 exhibits diverse effects, encompassing receptor binding, ion channel modulation, and enzyme inhibition. This peptide displays binding affinity towards a range of receptors, notably G-protein coupled receptors (GPCRs) and ionotropic receptors. It also exerts modulatory control over ion channels, including potassium, sodium, and calcium channels. Moreover, SLIGRL-NH2 acts as an inhibitor for enzymes, impeding the activity of proteases and phosphatases.
SLIGRL-NH2 (CAS 171436-38-7) References
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- Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. | Fiorucci, S., et al. 2001. Proc Natl Acad Sci U S A. 98: 13936-41. PMID: 11717450
- Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion. | Kawao, N., et al. 2002. Br J Pharmacol. 135: 1292-6. PMID: 11877338
- Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. | Coelho, AM., et al. 2002. Gastroenterology. 122: 1035-47. PMID: 11910355
- Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats. | Kawao, N., et al. 2002. Jpn J Pharmacol. 89: 184-7. PMID: 12120762
- Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta. | Compton, SJ., et al. 2002. Can J Physiol Pharmacol. 80: 987-92. PMID: 12450065
- Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2. | Shimada, SG., et al. 2006. Eur J Pharmacol. 530: 281-3. PMID: 16356490
- Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells. | Nagataki, M., et al. 2008. Cell Biochem Funct. 26: 279-82. PMID: 17708577
- Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. | Zhang, XC. and Levy, D. 2008. Cephalalgia. 28: 276-84. PMID: 18254896
- Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and -independent pathways in mice. | Tsujii, K., et al. 2008. J Pharmacol Sci. 108: 385-8. PMID: 18987429
- Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch. | Akiyama, T., et al. 2009. J Neurophysiol. 102: 2176-83. PMID: 19625538
- [The effect of protease-activated receptor2 on rat apoptotic cardiomyocytes underwent ischemia reperfusion injury]. | Tong, XH., et al. 2009. Zhonghua Xin Xue Guan Bing Za Zhi. 37: 832-6. PMID: 20128384
- Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse. | Akiyama, T., et al. 2014. Neuroscience. 266: 38-46. PMID: 24530451
- A comparison of the effects of nifedipine, verapamil, and low-molecular-weight heparin on SLIGRL-NH₂-induced calcium influx through proteinase-activated receptor 2 activation. | Sun, J., et al. 2014. Pharmacology. 93: 216-9. PMID: 24942999
- Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism. | Zhang, Y., et al. 2018. Drug Des Devel Ther. 12: 2403-2411. PMID: 30122898
Inhibitor of:
Pma2.Activator of:
PAR-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLIGRL-NH2, 1 mg | sc-359903 | 1 mg | $82.00 |