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PAR-2 Antibody (SAM11) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect Proteinase-Activated Receptor 2 (PAR-2), also known as F2RL1 or PAR2, across mouse, rat, and human species using applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). PAR-2 monoclonal antibody (SAM11) targets an epitope mapped within amino acids 37-50 of the human PAR-2 protein, enabling precise identification and analysis of PAR-2 in various experimental settings. PAR-2 functions as a G protein-coupled receptor that plays a pivotal role in mediating inflammatory responses and pain perception by interacting with extracellular proteases like trypsin, which cleave and activate the receptor. Located on the cell surface, PAR-2 facilitates critical signal transduction pathways that regulate cellular responses to environmental stimuli, making its cellular localization essential for its role in physiological and pathological processes. Structurally, PAR-2 is characterized by its seven transmembrane domains, a feature that is crucial for its interaction with G proteins and subsequent intracellular signaling cascades. Understanding the structure of PAR-2 is vital for elucidating its mechanism of action and for the development of targeted therapeutics. PAR-2 monoclonal antibody (SAM11) is available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing versatile options for diverse research applications. PAR-2 monoclonal antibody (SAM11) is an invaluable tool for researchers investigating the molecular mechanisms of PAR-2-mediated cellular functions and its implications in diseases such as inflammation, making a critical component in advancing biomedical research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAR-2 Antibody (SAM11) | sc-13504 | 200 µg/ml | $316.00 | |||
PAR-2 Antibody (SAM11): m-IgG Fc BP-HRP Bundle | sc-525471 | 200 µg Ab; 10 µg BP | $354.00 | |||
PAR-2 Antibody (SAM11): m-IgG2a BP-HRP Bundle | sc-546273 | 200 µg Ab; 10 µg BP | $354.00 | |||
PAR-2 Antibody (SAM11) L | sc-13504 L | 200 µg/0.1 ml | $316.00 | |||
PAR-2 Antibody (SAM11) AC | sc-13504 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PAR-2 Antibody (SAM11) HRP | sc-13504 HRP | 200 µg/ml | $316.00 | |||
PAR-2 Antibody (SAM11) FITC | sc-13504 FITC | 200 µg/ml | $330.00 | |||
PAR-2 Antibody (SAM11) PE | sc-13504 PE | 200 µg/ml | $343.00 | |||
PAR-2 Antibody (SAM11) Alexa Fluor® 488 | sc-13504 AF488 | 200 µg/ml | $357.00 | |||
PAR-2 Antibody (SAM11) Alexa Fluor® 546 | sc-13504 AF546 | 200 µg/ml | $357.00 | |||
PAR-2 Antibody (SAM11) Alexa Fluor® 594 | sc-13504 AF594 | 200 µg/ml | $357.00 | |||
PAR-2 Antibody (SAM11) Alexa Fluor® 647 | sc-13504 AF647 | 200 µg/ml | $357.00 | |||
PAR-2 Antibody (SAM11) Alexa Fluor® 680 | sc-13504 AF680 | 200 µg/ml | $357.00 | |||
PAR-2 Antibody (SAM11) Alexa Fluor® 790 | sc-13504 AF790 | 200 µg/ml | $357.00 |