PALD activators belong to a unique class of chemical agents designed to interact with and modulate the activity of the PALD enzyme. PALD, an acronym that stands for a specific enzyme found within various biological systems, plays a crucial role in a particular biochemical pathway. The activators are typically small molecules that can cross cell membranes and reach the intracellular environment where the PALD enzyme is located. Upon interaction with the PALD enzyme, these activators bind to the enzyme's active site or to an allosteric site, which is a different region of the enzyme that can influence its activity. The binding is typically highly specific, ensuring that the activator affects only the PALD enzyme and not other enzymes or proteins within the cell.
The design of PALD activators is grounded in complex organic chemistry and often requires a deep understanding of the enzyme's structure and the dynamics of its active site. The activators are crafted to fit precisely within the targeted region of the PALD enzyme, often mimicking the natural substrate or interacting with key amino acids that are crucial for the enzyme's catalytic function. By enhancing the enzyme's activity, these molecules alter the rate at which the PALD enzyme catalyzes its specific reaction within the biochemical pathway. The activation process can lead to a cascade of events within the cell, as the enhanced activity of the PALD enzyme can significantly influence the concentrations of various metabolites and intermediates involved in the pathway. The specificity and potency of PALD activators make them a focal point of interest in the realm of biochemical research, providing insights into enzyme regulation and the complex interplay of metabolic processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels, which can enhance PALD activity by cAMP-dependent protein kinase (PKA) signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, indirectly maintaining higher levels of PKA activity that can enhance PALD signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate various substrates, potentially increasing PALD activity as PKC is involved in numerous cellular signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, possibly leading to the activation of calcium-dependent kinases and phosphatases that modulate PALD's activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist leading to the activation of adenylate cyclase and an increase in cAMP levels, which can enhance PALD activity through PKA. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor, increasing cAMP levels in the cells, which can lead to enhanced PALD activity through PKA signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit various protein kinases, potentially reducing negative regulatory effects on PALD and indirectly enhancing its activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs), which could lead to the enhancement of PALD activity as part of the stress response pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that activates PKA and can enhance PALD activity through cAMP-dependent signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of proteins, which could indirectly enhance PALD activity. | ||||||