p53CSV Activators refers to a specific chemical class that has garnered attention within the realm of molecular biology and cellular signaling. At its core, these activators are designed to modulate the activity of the p53 protein, a pivotal player in the intricate network of cellular responses to stress and damage. The p53 protein, often referred to as the "guardian of the genome," plays a crucial role in regulating the cell cycle and orchestrating cellular responses to various stressors, including DNA damage and oncogenic signals. The activation of p53 is associated with the induction of cell cycle arrest, DNA repair, and apoptosis, thereby acting as a key guardian against the propagation of damaged or mutated cells.
Chemically, p53CSV Activators are characterized by their ability to specifically interact with and modulate the conformational state of the p53 protein. These small molecules or compounds are designed to elicit a response within the intricate machinery of cellular signaling pathways, influencing the activation or stabilization of p53. By doing so, p53CSV Activators aim to fine-tune the cellular responses mediated by p53, potentially enhancing its ability to exert control over the cell cycle and promote cellular integrity. The nuanced interaction between these activators and the p53 protein underscores the delicate balance within cellular regulatory networks, providing researchers with a molecular tool to explore and manipulate cellular processes associated with stress response and genome maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Inhibits the interaction between p53 and its negative regulator, MDM2, allowing for p53 activation and potential indirect upregulation of TP53I3. | ||||||
PRIMA-1MET | 5291-32-7 | sc-361295 sc-361295A | 10 mg 25 mg | $153.00 $325.00 | 5 | |
Restores the function of mutated p53, which can lead to the indirect activation of TP53I3 by increasing p53 activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Causes DNA damage, a condition that stimulates the activity of p53, potentially leading to indirect activation of TP53I3. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Induces DNA damage, which activates p53 and may indirectly upregulate TP53I3. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Causes DNA damage that leads to p53 activation, which can indirectly influence TP53I3 expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Induces DNA damage, leading to p53 activation and potentially indirect upregulation of TP53I3. | ||||||
p53 Activator III, RITA | 213261-59-7 | sc-202753 sc-202753A sc-202753B sc-202753C | 1 mg 10 mg 100 mg 500 mg | $112.00 $273.00 $1564.00 $5205.00 | 9 | |
Prevents p53-MDM2 interaction, leading to p53 activation and potential indirect activation of TP53I3. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Inhibits SIRT1 and SIRT2, proteins that deacetylate and thus deactivate p53, potentially leading to indirect activation of TP53I3. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Causes DNA damage that activates p53, which may subsequently indirectly upregulate TP53I3. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits topoisomerase, causing DNA damage and p53 activation, potentially leading to indirect activation of TP53I3. | ||||||