Date published: 2026-4-24

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p53CSV Activators

p53CSV Activators refers to a specific chemical class that has garnered attention within the realm of molecular biology and cellular signaling. At its core, these activators are designed to modulate the activity of the p53 protein, a pivotal player in the intricate network of cellular responses to stress and damage. The p53 protein, often referred to as the "guardian of the genome," plays a crucial role in regulating the cell cycle and orchestrating cellular responses to various stressors, including DNA damage and oncogenic signals. The activation of p53 is associated with the induction of cell cycle arrest, DNA repair, and apoptosis, thereby acting as a key guardian against the propagation of damaged or mutated cells.

Chemically, p53CSV Activators are characterized by their ability to specifically interact with and modulate the conformational state of the p53 protein. These small molecules or compounds are designed to elicit a response within the intricate machinery of cellular signaling pathways, influencing the activation or stabilization of p53. By doing so, p53CSV Activators aim to fine-tune the cellular responses mediated by p53, potentially enhancing its ability to exert control over the cell cycle and promote cellular integrity. The nuanced interaction between these activators and the p53 protein underscores the delicate balance within cellular regulatory networks, providing researchers with a molecular tool to explore and manipulate cellular processes associated with stress response and genome maintenance.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Nutlin-3

548472-68-0sc-45061
sc-45061A
sc-45061B
1 mg
5 mg
25 mg
$62.00
$225.00
$779.00
24
(1)

Inhibits the interaction between p53 and its negative regulator, MDM2, allowing for p53 activation and potential indirect upregulation of TP53I3.

PRIMA-1MET

5291-32-7sc-361295
sc-361295A
10 mg
25 mg
$153.00
$325.00
5
(1)

Restores the function of mutated p53, which can lead to the indirect activation of TP53I3 by increasing p53 activity.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

Causes DNA damage, a condition that stimulates the activity of p53, potentially leading to indirect activation of TP53I3.

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$176.00
$426.00
43
(3)

Induces DNA damage, which activates p53 and may indirectly upregulate TP53I3.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$37.00
$152.00
11
(1)

Causes DNA damage that leads to p53 activation, which can indirectly influence TP53I3 expression.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$51.00
$231.00
$523.00
63
(1)

Induces DNA damage, leading to p53 activation and potentially indirect upregulation of TP53I3.

p53 Activator III, RITA

213261-59-7sc-202753
sc-202753A
sc-202753B
sc-202753C
1 mg
10 mg
100 mg
500 mg
$112.00
$273.00
$1564.00
$5205.00
9
(1)

Prevents p53-MDM2 interaction, leading to p53 activation and potential indirect activation of TP53I3.

Tenovin-6

1011557-82-6sc-224296
sc-224296A
1 mg
5 mg
$272.00
$1214.00
9
(1)

Inhibits SIRT1 and SIRT2, proteins that deacetylate and thus deactivate p53, potentially leading to indirect activation of TP53I3.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$138.00
$380.00
101
(4)

Causes DNA damage that activates p53, which may subsequently indirectly upregulate TP53I3.

Camptothecin

7689-03-4sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$58.00
$186.00
$94.00
21
(2)

Inhibits topoisomerase, causing DNA damage and p53 activation, potentially leading to indirect activation of TP53I3.