Date published: 2026-4-1

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p41-ARCa Activators

The chemical class known as p41-ARCa Activators represents a group of compounds that interact with a specific subset of cellular proteins, which are part of the regulatory machinery within cells. The designation p41-ARCa refers to a particular protein target whose activity is modulated by these molecules. Typically, activators in this class are designed to bind to the protein and induce a conformational change that increases its activity. The precise mechanism of action can vary depending on the specific structure and composition of each molecule within the class, but the overarching theme is the upregulation of the protein's natural function within the cell. The p41 portion of the name hints at a possibly standardized nomenclature for the protein target or the molecular weight or characteristic of the protein, while ARCa could refer to the specific domain or type of activity regulation the protein is involved with.

Chemically, p41-ARCa Activators are diverse, with structures that can range from small organic molecules to larger, more complex biologics. This diversity reflects the variety of approaches that can be taken to achieve activation of the target protein. The design of these molecules is often informed by detailed knowledge of the protein's structure, as well as the pathways it participates in. The activators must possess the ability to reach and interact with their target within the complex environment of the cell. This involves considerations of molecular stability, solubility, and specificity to ensure proper engagement with the p41-ARCa protein. Additionally, these activators often exhibit high affinity for their targets to ensure that a significant biological response is achieved upon binding. Molecular modeling and iterative chemical synthesis are typically employed in the development of these compounds to fine-tune these properties, resulting in a tailored interaction with the p41-ARCa protein that results in its enhanced activity.

SEE ALSO...

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP further activates protein kinase A (PKA), which can then phosphorylate p41-ARCa, enhancing its activity.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA acts as a potent activator of protein kinase C (PKC), which is known to phosphorylate and thereby enhance the activity of p41-ARCa.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$78.00
$270.00
80
(4)

Ionomycin increases intracellular calcium concentration, which can activate calcium/calmodulin-dependent protein kinases (CaMKs). These kinases can then phosphorylate and enhance the activity of p41-ARCa.

Isoproterenol Hydrochloride

51-30-9sc-202188
sc-202188A
100 mg
500 mg
$28.00
$38.00
5
(0)

As a β-adrenergic agonist, Isoproterenol stimulates adenylyl cyclase, increasing cAMP levels, and subsequently activating PKA that can enhance the activity of p41-ARCa through phosphorylation.

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$47.00
$136.00
$492.00
$4552.00
74
(7)

db-cAMP is a cell-permeable cAMP analog that directly activates PKA. Activated PKA can phosphorylate p41-ARCa, thus enhancing its function.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$291.00
$530.00
$1800.00
78
(4)

Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, preventing dephosphorylation of p41-ARCa, thereby maintaining it in an active phosphorylated state.

Calyculin A

101932-71-2sc-24000
sc-24000A
10 µg
100 µg
$163.00
$800.00
59
(3)

Similar to okadaic acid, Calyculin A inhibits protein phosphatases 1 and 2A, leading to sustained phosphorylation and activity of p41-ARCa.

(−)-Epinephrine

51-43-4sc-205674
sc-205674A
sc-205674B
sc-205674C
sc-205674D
1 g
5 g
10 g
100 g
1 kg
$41.00
$104.00
$201.00
$1774.00
$16500.00
(1)

Epinephrine interacts with β-adrenergic receptors to increase intracellular cAMP levels, leading to the activation of PKA, which can then phosphorylate and enhance the activity of p41-ARCa.

Rolipram

61413-54-5sc-3563
sc-3563A
5 mg
50 mg
$77.00
$216.00
18
(1)

Rolipram inhibits phosphodiesterase 4 (PDE4), leading to increased cAMP levels and PKA activity. PKA then enhances the activity of p41-ARCa through phosphorylation.

FPL-64176

120934-96-5sc-201491
5 mg
$83.00
1
(1)

FPL 64176 is a calcium channel agonist that increases intracellular calcium levels, subsequently activating CaMKs that can phosphorylate and enhance p41-ARCa activity.